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It is now well established that the immune system contributes to pathological pain sates and one relatively under studied aspect of this is through the action of autoantibodies. Neuropathic pain is common in patients with autoantibodies directed against components of the voltage gated potassium channel complex such as CASPR2 and LGI1. By using patient samples in combination with basic pain research my aim is to better understand the mechanisms of autoantibody mediated pain and by doing so uncover novel molecular pathways regulating pain sensitivity as well as revealing clinically relevant targets for the development of future therapies.
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Frontiers in molecular neuroscience (2023): 1254854-1254854
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Frontiers in molecular neuroscience (2023): 1336871-1336871
Bo Sun, Deniz Akdeniz, Anne-Katrin Kienzler, Jeanne Tan,Melanie Ramberger,John Dawes, Teodora Trendafilova,David Bennett,Patrick Waters,Sarosh Irani
Journal of Neurology, Neurosurgery & Psychiatryno. 6 (2022): A4.1-A4
Annals of neurologyno. 4 (2021): 683-690
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