基本信息
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Bio
My research is focused on understanding the role of inflammation in diabetic heart disease. Toll-like receptors (TLRs) play a critical role in host defense against pathogens, but they are also activated by noninfectious cellular stress, such as that which occurs in lipid overload, diabetes, and ischemia. My lab is using a combination of cell culture and in vivo models of heart failure and lipotoxic stress to define the mechanisms by which TLR-inflammatory pathways are activated and to address the functional consequences of these pathways in the development and progression of cardiomyopathy. Through this research we hope to create a platform for translational studies involving human subjects with diabetes and heart failure. Ultimately, this work aspires to identify novel targets for treating, and perhaps preventing, heart failure in patients with diabetes.
Research Interests
Papers共 155 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
JTCVS Techniques (2024): 63-71
JACC Heart Failure (2024)
David S Lambert, Ana Maria Pico, Justin D Vincent,Elena Deych,Erin Coglianese,Joel D Schilling,Justin Marinus Vader,Bin Quan Yang
medrxiv(2024)
Journal of immunology (Baltimore, Md. : 1950)no. 3 (2024): 251-256
Xiangyu Zhang,Divya Kapoor,Se-Jin Jeong,Alan Fappi,Jeremiah Stitham, Vasavi Shabrish,Ismail Sergin, Eman Yousif,Astrid Rodriguez-Velez,Yu-Sheng Yeh,Arick Park,Arif Yurdagul Jr,Oren Rom,Slava Epelman,Joel D. Schilling, Marco Sardiello,Abhinav Diwan,Jaehyung Cho,Nathan O. Stitziel,Ali Javaheri,Irfan J. Lodhi,Bettina Mittendorfer,Babak Razani
Nature Metabolismno. 2 (2024): 359-377
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERYno. 4 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Author Statistics
#Papers: 155
#Citation: 10360
H-Index: 38
G-Index: 101
Sociability: 6
Diversity: 0
Activity: 2
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