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Bio
I have worked in the preclinical pain field since 1985. There is little reason to do such work unless it leads to new pain therapies. Fortunately we have identified a number of new analgesic targets in studies of transgenic mice. An ATP-gated channel that I identified in Geoff Burnstock's department has resulted in a new treatment for chronic cough in the clinic. The drug is called Gefapixant in honour of Geoff! We also cloned a sodium channel named Nav1.8 that is very important for human pain, and Vertex have produced a channel blocker that has succeded in phase 3 trials. Most recently we showed that Nav1.7, another sodium channel, plays a key role in pain, and explained the mechanism behind this. Our recent work focusses on chemogenetic studies of bone cancer pain, where we have had preclinical success.
Research Interests
Papers共 337 篇Author StatisticsCo-AuthorSimilar Experts
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biorxiv(2024)
CELL REPORTSno. 8 (2024)
biorxiv(2024)
Cell reportsno. 6 (2024): 114334-114334
Pain (2024)
Annette Lischka,Katja Eggermann,Christopher J. Record,Maike F. Dohrn,Petra Lassuthova,Florian Kraft,Matthias Begemann,Daniela Dey,Thomas Eggermann,Danique Beijer,Jana Soukalova,Matilde Laura,Alexander M. Rossor,Radim Mazanec,Jonas Van Lent,Pedro J. Tomaselli,Martin Ungelenk, Karlien Y. Debus,Shawna M. E. Feely,Dieter Glaeser,Sujatha Jagadeesh,Madelena Martin, Geeta M. Govindaraj,Pratibha Singhi, Revanth Baineni,Niranjan Biswal,Marisol Ibarra-Ramirez,Maryse Bonduelle,Burkhard Gess, Juan Romero Sanchez,Renu Suthar,Vrajesh Udani,Atchayaram Nalini,Gopikrishnan Unnikrishnan,Wilson Marques Junior,Sandra Mercier,Vincent Procaccio,Celine Bris,Beena Suresh,Vaishnavi Reddy,Mariola Skorupinska,Nathalie Bonello-Palot,Fanny Mochel, Georg Dahl, Karthika Sasidharan,Fiji M. Devassikutty,Sheela Nampoothiri,Maria J. Rodovalho Doriqui,Wolfgang Mueller-Felber,Katharina Vill,Tobias B. Haack,Andreas Dufke,Michael Abele,Rolf Stucka,Saima Siddiqi,Noor Ullah,Stephanie Spranger,Deborah Chiabrando, Behiye S. Bolgul,Yesim Parman,Pavel Seeman,Angelika Lampert,Joerg B. Schulz,John N. Wood,James J. Cox,Michaela Auer-Grumbach,Vincent Timmerman,Jonathan de Winter,Andreas C. Themistocleous,Michael Shy,David L. Bennett,Jonathan Baets,Christian A. Huebner,Enrico Leipold,Stephan Zuchner,Miriam Elbracht,Arman Cakar,Jan Senderek,Thorsten Hornemann,C. Geoffrey Woods,Mary M. Reilly,Ingo Kurth
Jing Wang,Qiao-min Ru,Xiao-hui Yu, Changlong Wang,Kai Li,Chao-zhen-yi Han,Na Li, Jing Zhao,John N. Wood,Xin Liu,Rui Wang,Yuan Wang
EUROPEAN JOURNAL OF PHARMACOLOGY (2023)
Brainno. 9 (2023): 3851-3865
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 17 (2023)
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Author Statistics
#Papers: 336
#Citation: 28103
H-Index: 83
G-Index: 164
Sociability: 7
Diversity: 0
Activity: 1
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