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个人简介
While at the NCI, Dr. Roth completed the first randomized clinical trials of neoadjuvant chemotherapy for squamous carcinoma of the esophagus and open lung biopsy in immunocompromised patients with diffuse pulmonary infiltrates. At UTMDACC, Dr. Roth has initiated and acted as the principal investigator of the first gene therapy trials for lung cancer. Dr. Roth has spearheaded the development of institutional multidisciplinary protocols in thoracic oncology and was the principal investigator of the first randomized trial showing survival benefit with neoadjuvant chemotherapy in stage IIIA resectable lung cancer.
Among his landmark achievements, Dr. Roth was principal investigator for the first tumor suppressor gene therapy clinical trials approved by the National Institutes of Health Recombinant DNA Advisory Committee and the U.S. Food and Drug Administration. Approval for those historic protocols was based on his demonstrating feasibility and efficacy through laboratory and preclinical studies. His team showed that restoration of function for a single normal tumor suppressor gene could mediate regression of human cancers in vivo, helped identify and characterize a number of novel tumor suppressor genes on chromosome 3, and found that systemic delivery of tumor suppressor genes using a nanoparticle vector could effectively treat disseminated human lung cancer in animal models. These observations led Dr. Roth and colleagues to initiate the first clinical trial using nanoparticles to deliver genes systemically. Cancer gene therapy developed in his laboratory became the first gene therapy to be approved for human use. In addition to being an international leader in developing gene therapy for lung and other cancers, he has trained a new generation of outstanding surgical oncologists and laboratory researchers who are applying his philosophy of excellence throughout the world.
Among his landmark achievements, Dr. Roth was principal investigator for the first tumor suppressor gene therapy clinical trials approved by the National Institutes of Health Recombinant DNA Advisory Committee and the U.S. Food and Drug Administration. Approval for those historic protocols was based on his demonstrating feasibility and efficacy through laboratory and preclinical studies. His team showed that restoration of function for a single normal tumor suppressor gene could mediate regression of human cancers in vivo, helped identify and characterize a number of novel tumor suppressor genes on chromosome 3, and found that systemic delivery of tumor suppressor genes using a nanoparticle vector could effectively treat disseminated human lung cancer in animal models. These observations led Dr. Roth and colleagues to initiate the first clinical trial using nanoparticles to deliver genes systemically. Cancer gene therapy developed in his laboratory became the first gene therapy to be approved for human use. In addition to being an international leader in developing gene therapy for lung and other cancers, he has trained a new generation of outstanding surgical oncologists and laboratory researchers who are applying his philosophy of excellence throughout the world.
研究兴趣
论文共 943 篇作者统计合作学者相似作者
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Haniel A Araujo, Ximo Pechuan-Jorge,Teng Zhou,Minh Truong Do, Xin Hu,Frank R Rojas Alvarez, Maria E Salvatierra, Heladio P Ibarguen, Richard Lee, Rashi Raghulan,Harshit Shah, Mariela A Moreno Ayala,Kevin Chen,Nataliya Tovbis Shifrin,Shuhong Wu,Luisa M Solis Soto,Marcelo V Negrao,Don L Gibbons,David S Hong,Jack A Roth,John V Heymach,Jianjun Zhang, Jingjing Jiang,Mallika Singh,Jacqueline A M Smith,Elsa Quintana,Ferdinandos Skoulidis
Cancer discovery (2024)
DISEASES OF THE ESOPHAGUSno. 6 (2024)
Annals of surgery (2024)
Franziska Haderk,Yu-Ting Chou,Lauren Cech,Celia Fernandez-Mendez,Johnny Yu,Victor Olivas,Ismail M. Meraz,Dora Barbosa Rabago,D. Lucas Kerr,Carlos Gomez,David V. Allegakoen,Juan Guan,Khyati N. Shah,Kari A. Herrington,Oghenekevwe M. Gbenedio,Shigeki Nanjo,Mourad Majidi,Whitney Tamaki, Yashar K. Pourmoghadam,Julia K. Rotow,Caroline E. McCoach,Jonathan W. Riess,J. Silvio Gutkind,Tracy T. Tang,Leonard Post,Bo Huang,Pilar Santisteban,Hani Goodarzi,Sourav Bandyopadhyay,Calvin J. Kuo,Jeroen P. Roose,Wei Wu,Collin M. Blakely,Jack A. Roth,Trever G. Bivona
Cancer Researchno. 6_Supplement (2024): 1420-1420
Ismail M. Meraz,Shuhong Wu,Mourad Majidi,Chenghui Ren, Yi Xu,Feng Meng,Lihui Gao,Renduo Song, Ran Zhang,Bingliang Fang,Qi Wang,Yuanxin Xi, Jing Wang,Sung Yun Jung,Jack A. Roth
Cancer Researchno. 6_Supplement (2024): 1929-1929
Ferdinandos Skoulidis, Haniel A Araujo, Minh Truong Do,Yu Qian, Xin Sun,Ana Galan Cobo, John T Le,Meagan Montesion, Rachael Palmer,Nadine Jahchan,Joseph M Juan,Chengyin Min,Yi Yu,Xuewen Pan,Kathryn C Arbour,Natalie Vokes, Stephanie T Schmidt,David Molkentine,Dwight H Owen,Regan Memmott, Pradnya D Patil,Melina E Marmarelis,Mark M Awad,Joseph C Murray,Jessica A Hellyer,Justin F Gainor, Anastasios Dimou, Christine M Bestvina,Catherine A Shu,Jonathan W Riess,Collin M Blakely,Chad V Pecot,Laura Mezquita,Fabrizio Tabbó,Matthias Scheffler,Subba Digumarthy,Meghan J Mooradian,Adrian G Sacher, Sally C M Lau, Andreas N Saltos,Julia Rotow, Rocio Perez Johnson, Corinne Liu,Tyler Stewart,Sarah B Goldberg, Jonathan Killam,Zenta Walther,Kurt Schalper, Kurtis D Davies, Mark G Woodcock,Valsamo Anagnostou,Kristen A Marrone, Patrick M Forde,Biagio Ricciuti,Deepti Venkatraman,Eliezer M Van Allen,Amy L Cummings,Jonathan W Goldman, Hiram Shaish, Melanie Kier,Sharyn Katz,Charu Aggarwal,Ying Ni, Joseph T Azok,Jeremy Segal, Lauren Ritterhouse,Joel W Neal, Ludovic Lacroix,Yasir Y Elamin, Marcelo V Negrao, Xiuning Le,Vincent K Lam,Whitney E Lewis,Haley N Kemp,Brett Carter,Jack A Roth,Stephen Swisher,Richard Lee, Teng Zhou,Alissa Poteete, Yifan Kong, Tomohiro Takehara, Alvaro Guimaraes Paula,Edwin R Parra Cuentas,Carmen Behrens,Ignacio I Wistuba,Jianjun Zhang,George R Blumenschein,Carl Gay,Lauren A Byers,Don L Gibbons,Anne Tsao,J Jack Lee,Trever G Bivona,D Ross Camidge, Jhannelle E Gray, Natasha Lieghl, Benjamin Levy,Julie R Brahmer,Marina C Garassino,David R Gandara,Edward B Garon,Naiyer A Rizvi,Giorgio Vittorio Scagliotti,Jürgen Wolf,David Planchard,Benjamin Besse,Roy S Herbst,Heather A Wakelee,Nathan A Pennell,Alice T Shaw,Pasi A Jänne,David P Carbone,Matthew D Hellmann,Charles M Rudin,Lee Albacker,Helen Mann, Zhou Zhu,Zhongwu Lai,Ross Stewart,Solange Peters,Melissa L Johnson, Kwok K Wong,Alan Huang,Monte M Winslow,Michael J Rosen, Ian P Winters,Vassiliki A Papadimitrakopoulou,Tina Cascone, Philip Jewsbury,John V Heymach
Nature (2024)
Hope Feldman,Boris Sepesi,Cheuk H. Leung,Heather Lin,Annikka Weissferdt,Apar Pataer,William N. William Jr,Garrett L. Walsh,David C. Rice,Jack A. Roth,Reza J. Mehran,Wayne L. Hofstetter,Mara B. Antonoff,Ravi Rajaram,Don L. Gibbons,J. Jack Lee,John V. Heymach,Ara A. Vaporciyan,Stephen G. Swisher,Tina Cascone
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERYno. 4 (2024)
Funda Meric-Bernstam,Michael W. Lloyd,Soner Koc,Yvonne A. Evrard,Lisa M. Mcshane,Michael T. Lewis,Kurt W. Evans,Dali Li,Lawrence Rubinstein,Alana Welm,Dennis A. Dean,Anuj Srivastava,Jeffrey W. Grover,Min J. Ha,Huiqin Chen,Xuelin Huang,Kaushik Varadarajan, Jing Wang,Jack A. Roth,Bryan Welm, Ramaswamy Govinden,Li Ding,Salma Kaochar,Nicholas Mitsiades,Luis Carvajal-Carmona,Meenhard Herylyn,Michael A. Davies,Geoffrey I. Shapiro,Ryan Fields,Jose G. Trevino,Joshua C. Harrell,James H. Doroshow,Jeffrey H. Chuang,Jeffrey A. Moscow
Molecular cancer therapeuticspp.OF1-OF15, (2024)
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作者统计
#Papers: 944
#Citation: 49089
H-Index: 109
G-Index: 192
Sociability: 8
Diversity: 3
Activity: 186
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