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Dr. Coller has joint appointments in both the Biology department, as well as the Molecular Biology & Genetics department at the School of Medicine. Now we study how regulation is built into this system by looking at 1] how the mRNA degradation machinery interacts with the ribosome 2] how features such as RNA modifications can impact codon optimality and 3] how tRNA biology can ultimately impact mRNA levels. Lastly, we are harnessing these discoveries, pushing open this exciting field, and leveraging our findings towards the development of novel therapeutics.
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Nature Reviews Drug Discoveryno. 2 (2024): 108-125
Yoo-Ah Kim, Kambiz Mousavi, Amirali Yazdi, Magda Zwierzyna, Marco Cardinali, Dillion Fox, Thomas Peel,Jeff Coller,Kunal Aggarwal,Giulietta Maruggi
VACCINEno. 7 (2024): 1831-1840
Methods in molecular biology (Clifton, N.J.) (2024): 161-172
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