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Dr. Hawdon's research interests focus around the hookworm infectious process. The developmentally arrested infective stage receives a host-specific signal that re-initiates suspended developmental pathways that culminate in development of the adult parasite. Dr. Hawdon's laboratory is investigating the molecular events of this activation to parasitism in the framework of dauer recovery in the free-living nematode Caenorhabditis elegans. Using a novel in vitro activation assay that Dr. Hawdon developed, his lab confirmed that hookworm infective larvae use the same signaling pathways during activation that C. elegans dauers use during recovery. Dr. Hawdon is continuing to dissect the pathways in hookworm larvae by identifying the host-specific signal and its receptor, the molecules involved in the transduction of this signal, and the molecular events of development. Dr. Hawdon is also interested in the population genetics of natural populations of hookworms infecting humans. His studies have demonstrated the presence of genetically isolated populations of the human hookworm Necator americanus in China. Variation in hookworm populations will complicate the design of recombinant vaccines and effective drug-based control strategies. Future studies will investigate the effect of transmission patterns on the intra- and interhost population genetics of hookworms. Dr. Hawdon is also pursuing sanitation-based control strategies for soil transmitted helminths in China.
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PARASITOLOGYpp.1-44, (2024)
biorxiv(2024)
PARASITOLOGYno. 1 (2024): 102-107
microPublication biology (2023)
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Parasitologyno. 6 (2023): 511-523
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Barbara B Warner,Bruce A Rosa,I Malick Ndao,Phillip I Tarr,J Philip Miller,Sarah K England,Joan L Luby,Cynthia E Rogers,Carla Hall-Moore, Renay E Bryant, Jacqueline D Wang,Laura A Linneman,
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