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Our group studies the structure and function of macromolecular assemblies using electron cryomicroscopy (cryo-EM), image analysis, molecular biology and molecular genetics. We also develop the tools of cryo-EM so that we can answer questions that are not amenable to the techniques that currently exist. This process usually occurs at the level of developing new algorithms and software for image analysis and performing calculations with images and models of molecular structure.
Recent biological projects have included the structural study of the mitochondrial ATP synthase, the Vacuolar-type ATPase, and the V/A-ATPase. We also study bacterial toxins that interact with mammalian cells.
Recent biological projects have included the structural study of the mitochondrial ATP synthase, the Vacuolar-type ATPase, and the V/A-ATPase. We also study bacterial toxins that interact with mammalian cells.
研究兴趣
论文共 168 篇作者统计合作学者相似作者
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MOLECULAR CELLno. 3 (2024): 429-446.e17
Claire E. Coupland, Ryan Karimi,Stephanie A. Bueler,Yingke Liang,Gautier M. Courbon,Justin M. Di Trani,Cassandra J. Wong, Rayan Saghian, Ji-Young Youn,Lu-Yang Wang,John L. Rubinstein
crossref(2024)
Duc Minh Nguyen, Deanna H Rath,Dominic Devost,Darlaine Pétrin, Robert Rizk,Alan X Ji,Naveen Narayanan, Darren Yong,Andrew Zhai,Douglas A Kuntz, Maha U Q Mian,Neil C Pomroy,
Proceedings of the National Academy of Sciences of the United States of Americano. 17 (2024): e2315018121-e2315018121
biorxiv(2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 40 (2023)
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Science Translational Medicineno. 697 (2023)
biorxiv(2023)
The Journal of biological chemistryno. 1 (2023): 105483-105483
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