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Research interests include determining protein structures and studying the structure/function of complexes formed with drugs and natural ligands. Key developments in recent years includes (i) Determination of the first structure of an integrin/collagen complex. This structure revealed the molecular basis of the contacts formed between cells and the extracellular matrix. (ii) Determination of the platelet receptor glycoprotein Ib extracellular domain and von Willebrand factor A1 domain structures (iii) determination of the coagulation factor xi structure. These proteins are vital to normal platelet adhesion and hemostatic function. We also have collaborative interests in determining structures of protein complexes formed with anti-cancer and anti-thrombosis inhibitors. These structures provide scaffolds which can pave the way for design of improved therapeutic agents.
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论文共 138 篇作者统计合作学者相似作者
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Fadi Soukarieh,Alaa Mashabi,William Richardson,Eduard Vico Oton,Manuel Romero,Jean-Frederic Dubern, Shaun N. Robertson, Simone Lucanto,Zoe Markham-Lee,Tomas Sou,Irena Kukavica-Ibrulj,Roger C. Levesque,
JOURNAL OF MEDICINAL CHEMISTRYno. 2 (2024): 1008-1023
Nicholas A. Arce,Zoe Markham-Lee, Qian Liang, Shabir Najmudin,Emily R. Legan, Gabrielle Dean, Ally J. Su,Moriah S. Wilson,Robert F. Sidonio,Pete Lollar,Jonas Emsley,Renhao Li
Blood (2024)
Journal of medicinal chemistryno. 2 (2024): 1008-1023
ACS medicinal chemistry lettersno. 4 (2024): 501-509
Sigrun K Maurer, Matthias P Mayer, Stephanie J Ward,Sana Boudjema, Mohamed Halawa, Jiatong Zhang,Simon G Caulton,Jonas Emsley,Ingrid Dreveny
The Journal of biological chemistryno. 11 (2023): 105300-105300
Research and Practice in Thrombosis and Haemostasis (2023): 100769-100769
Research and Practice in Thrombosis and Haemostasis (2023): 100328-100328
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