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个人简介
A major research aim in the Miano Lab has been to decipher the small snippets of codes in our genome that dictate how genes involved in cardiovascular disease are either turned up or down. Much like a thermostat controlling the heat in a home, cells normally have exquisite control over the level of gene activity. Diseases of the heart and blood vessels occur when this 'geneostat' control runs awry. Thus, identifying and understanding how certain genetic codes control genes turning on and off is a foundation for developing novel methods of predicting and perhaps treating various diseases of the body. Dr. Miano's lab was among the first wave of labs in 2013 to exploit the revolutionary CRISPR genome editing technology for purposes of altering the mouse genome and, within a year, the lab generated the first CRISPR animal model carrying subtle mutations in a control element that turns on a gene (Cnn1). To date, Dr. Miano has published over 100 research papers that focus on the control of gene expression in smooth muscle cells of the blood vessel wall. He previously served as Associate Editor of ATVB and Consulting Editor of Circulation Research. He is a Fellow of the American Heart Association and a member of the Vascular Cell and Molecular Biology Study Section at NIH.
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论文共 212 篇作者统计合作学者相似作者
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Amr R. Salem,W. Bart Bryant,Jaser Doja, Susan H. Griffin,Xiaofan Shi,Weihong Han,Yunchao Su,Alexander D. Verin,Joseph M. Miano
VASCULAR PHARMACOLOGY (2024): 107269-107269
Lova Prasadareddy Kajuluri,Qing Rex Lyu,Jaser Doja,Ajay Kumar,Michael P. Wilson, Samantha R. Sgrizzi, Elika Rezaeimanesh,Joseph M. Miano,Kathleen G. Morgan
JOURNAL OF CELLULAR AND MOLECULAR MEDICINEno. 1 (2024): e18025-e18025
Arteriosclerosis, thrombosis, and vascular biologyno. 7 (2023): 1176-1178
Ganesh Warthi,Jessica L. Faulkner, Jaser Doja, Amr R. Ghanam,Pan Gao,Allison C. Yang,Orazio J. Slivano,Candee T. Barris,Taylor C. Kress,Scott D. Zawieja, Susan H. Griffin,Xiaoling Xie,
NATURE CARDIOVASCULAR RESEARCHno. 7 (2023): 702-702
Xavier Rambout, Hana Cho,Roméo Blanc, Qing Lyu,Joseph M Miano, Joe V Chakkalakal,Geoffrey M Nelson, Hari K Yalamanchili, Karen Adelman,Lynne E Maquat
bioRxiv : the preprint server for biology (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Wei Zhang,Jinjing Zhao,Lin Deng,Nestor Ishimwe,Jessica Pauli,Wen Wu,Shengshuai Shan, Wolfgang Kempf, Margaret D Ballantyne,David Kim,Qing Lyu, Matthew Bennett,
bioRxiv : the preprint server for biology (2023)
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