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Research Summary
Our overarching goal is to develop quantitative molecular platforms to detect and identify molecular interactomes of membrane proteins and determine their hierarchical organisation directly from the cellular environment with precise spatial and molecular resolution. To achieve this we exploit the cross-disciplinary expertise of our lab and combine nativeMS with a range of orthogonal quantitative approaches. Together, they provide unique quantitative tools to study membrane biology. Research in our lab spans from designing fundamentally novel experimental platform to studying specific membrane associated signaling pathways. Our special emphasis lies in understanding neural signaling and associated impairment in neurodegenerative diseases. Some of the key biological questions we are currently addressing are:
(i) How hierarchical organization of proteins and lipids at the synaptic vesicles regulate fast Ca2+ mediated release of neurotransmitter at the neuronal synapses?
(ii) How trafficking of lipids and proteins at the membrane contact site of the cellular organelles regulate cellular homeostasis and their impairments lead to different neurocognitive disorders?
Our overarching goal is to develop quantitative molecular platforms to detect and identify molecular interactomes of membrane proteins and determine their hierarchical organisation directly from the cellular environment with precise spatial and molecular resolution. To achieve this we exploit the cross-disciplinary expertise of our lab and combine nativeMS with a range of orthogonal quantitative approaches. Together, they provide unique quantitative tools to study membrane biology. Research in our lab spans from designing fundamentally novel experimental platform to studying specific membrane associated signaling pathways. Our special emphasis lies in understanding neural signaling and associated impairment in neurodegenerative diseases. Some of the key biological questions we are currently addressing are:
(i) How hierarchical organization of proteins and lipids at the synaptic vesicles regulate fast Ca2+ mediated release of neurotransmitter at the neuronal synapses?
(ii) How trafficking of lipids and proteins at the membrane contact site of the cellular organelles regulate cellular homeostasis and their impairments lead to different neurocognitive disorders?
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论文共 61 篇作者统计合作学者相似作者
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crossref(2024)
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crossref(2024)
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Caroline Brown, Snehasish Ghosh, Rachel McAllister,Mukesh Kumar, Gerard Walker, Eric Sun, Talat Aman,Aniruddha Panda,Shailesh Kumar,Wenxue Li,Jeff Coleman,Yansheng Liu,
bioRxiv : the preprint server for biology (2024)
crossref(2024)
Caroline Brown, Snehasish Ghosh, Rachel McAllister,Jeff Coleman, Eric Sun, Hong Zheng,Shailesh Kumar,Moitrayee Bhattacharyya,Kallol Gupta
Journal of Biological Chemistryno. 3 (2024)
NATURE MICROBIOLOGY (2024)
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