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Their current target- and phenotypically-driven drug discovery programmes against the causative agents of malaria, tuberculosis, antimicrobial resistance (drug- resistant infections of bacterial origin) and Covid-19 infections, has the main objective of delivering preclinical drug development candidates. An attendant objective is elucidating the mechanism of action, through target identification, of drug leads derived from the phenotypic whole- cell-based approach.
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ACS medicinal chemistry lettersno. 4 (2024): 463-469
Helenita Costa Quadros,Lars Herrmann, Jeanne Manaranche,Lucie Paloque, Mariana C. Borges-Silva,Godwin Akpeko Dziwornu, Sarah D’Alessandro,Kelly Chibale,Nicoletta Basilico,Françoise Benoit-Vical,Svetlana B. Tsogoeva,Diogo Rodrigo M. Moreira
biorxiv(2024)
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Science translational medicineno. 718 (2023)
Diego González Cabrera, Dennis A Smith,Gregory S Basarab,James Duffy, Thomas Spangenberg,Kelly Chibale
ACS medicinal chemistry lettersno. 7 (2023): 875-878
NATURE REVIEWS CHEMISTRY (2023)
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