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Based on our initial work in yeast, we described two major pathways of mRNA decay in eukaryotic cells. Both pathways begin with shortening of the 3' polyadenylate tail found on eukaryotic mRNAs (referred to as deadenylation), which primarily triggers decapping, leading to 5' to 3' exonucleolysis. Alternatively, removal of the 3' polyadenylate tail can expose the mRNA to 3' to 5' degradation. We have identified all the critical enzymes involved in these pathways. Evolutionary conservation of the critical mRNA decay factors and experimental evidence now indicate that these mechanisms of mRNA decay also play a major role in the turnover of mRNAs in mammalian cells. Given this fact, understanding the control of mRNA turnover in mammals will be greatly aided by understanding how the enzymes that catalyze mRNA degradation are regulated in yeast.
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The Journal of cell biologyno. 3 (2024)
Virology Journalno. 1 (2024): 1-18
Science advancesno. 5 (2024): eadk8152-eadk8152
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatrypp.10738584231154551-107385842311545, (2023)
RNA biologyno. 1 (2023): 444-456
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mBiono. 6 (2023)
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