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Research Overview
Cell-cell communication is essential for the proper manifestation of many events that take place during the development of multi-cellular organisms, including fate specification, cell shape change and migration, growth, and differentiation. We are interested in the underlying molecular mechanisms that mediate cell signaling during these developmental events, as well as the developmental consequences associated with signaling dysfunction. Throughout my career I have merged the use of genetic manipulation with cell and molecular analyses to dissect complex processes revealing how cells interact. We are particularly interested in the regulation of signaling output by the BMP pathway. Central to our research has been an elucidation of the molecular mechanisms underlying the regulation of this potent signaling pathway. Our research in the Drosophila model system has led to new discoveries with regard to regulating ligand production and differential receptor contribution in the signaling complex. We are currently applying these findings to studies of ALS, cleft lip and/or palate and fibrodysplasia ossificans progressiva (FOP).
研究兴趣
论文共 47 篇作者统计合作学者相似作者
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Jay C. Groppe,Guorong Lu,Mary R. Tandang-Silvas, Anupama Pathi, Shruti Konda,Jingfeng Wu,Viet Q. Le,Andria L. Culbert,Eileen M. Shore,Kristi A. Wharton,Frederick S. Kaplan
BIOMOLECULESno. 7 (2023): 1129-1129
GENETICSno. 2 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
biorxiv(2021)
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