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个人简介
Bioanalytical chemistry, neurochemistry, biological mass spectrometry, neuropeptides, proteomics, peptidomics
Research in my laboratory is focused on developing and implementing an array of novel mass spectrometry (MS)
based methodologies to answer questions about the most complex and elusive set of signaling molecules, the
neuropeptides, and gain new insights into the roles of peptide hormones and neurotransmitters play in the plasticity
of neural circuits and behavior. Emphasis has been placed on constructing a multi-faceted and integrated platform
that include high resolution in-situ peptide mapping, high sensitivity micro-separation techniques coupled with
tandem MS de novo sequencing, isotopic labeling strategies, and new bioinformatics tools to allow large-scale
discovery and functional analysis of novel neuropeptides. Furthermore, both mass spectrometric imaging
technologies and in vivo microdialysis sampling tools have been implemented to follow neuropeptide distribution
and secretion in unprecedented details. Towards the goal of functional discovery of bioactive neuropeptides, novel
quantitative schemes and new isobaric tagging reagents based on dimethylated amino acids have been developed to
produce differential display of neuropeptidomes under several physiological conditions, including food intake,
environmental stress, and neural network development. Additionally, lectin-based affinity enrichment strategies
have been developed in conjunction with isotopic labeling for comparative glycoproteomics and membrane
proteomics for biomarker discovery in neurodegenerative diseases.
研究兴趣
论文共 408 篇作者统计合作学者相似作者
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ANALYTICAL CHEMISTRYno. 9 (2024): 3870-3878
Hao Chen, Yunlin Fu, Mei Han,Xianlin Han,Ling Hao,Tao Huan,Lan Huang,Ming Huang, Qin Ji, Tao Jiang,Yong Jiang,Liang Li,
Ting-Jia Gu, Peng-Kai Liu, Yen-Wen Wang,Matthew T. Flowers, Shuling Xu,Yuan Liu,Dawn B. Davis,Lingjun Li
Feng He,Cheng-Guo Wu,Yang Gao, Sabrina N. Rahman, Magda Zaoralova,Makaia M. Papasergi-Scott,Ting-Jia Gu,Michael J. Robertson,Alpay B. Seven,Lingjun Li,Jesper M. Mathiesen,Georgios Skiniotis
NATUREno. 8001 (2024): 1141-1148
Analytical Chemistry (2024)
The journals of gerontology. Series A, Biological sciences and medical sciencesno. 6 (2024)
Methods in molecular biology (Clifton, N.J.) (2024): 445-455
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