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Our specific interests are understanding the biogenesis of post-Golgi compartments, how newly synthesised proteins are delivered from the Golgi complex to these compartments and how cells achieve sorting and delivery of endocytosed macromolecules to lysosomes. Lysosomes are now recognised to be dynamic organelles receiving membrane traffic input from the biosynthetic, endocytic and autophagic pathways. They are capable of fusing with late endosomes to form hybrid organelles where digestion of endocytosed macromolecules occurs and from which lysosomes are re-formed. Lysosomes can also fuse with the plasma membrane in response to cell surface damage to effect membrane repair. A key protein for these fusion processes is the membrane protein Vamp7. We have discovered binding partners of Vamp7 which appear to be involved in either ensuring that Vamp7 traffics correctly to lysosomes, or in regulating its function. We are also studying the function of ESCRT (endosomal sorting complex required for transport) proteins in health and disease and searching for novel proteins involved in post-Golgi membrane traffic using siRNA knockdown techniques. We are particularly interested in interactions between the protein complexes involved in mediating traffic through the endocytic pathway to lysosomes.
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Molecular biology of the cellpp.mbcE23080322-mbcE23080322, (2024)
Elena V Pavlova,Aleksey Shatunov,Lena Wartosch, Alena I Moskvina, Lena E Nikolaeva,Nicholas A Bright,Karen L Tylee,Heather J Church,Andrea Ballabio,J Paul Luzio,Timothy M Cox
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