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He has specific interest in the Complement System and diseases associated with defects in this system. Major field of research has been Angioedema and particularly the form associated with deficiency of C1 inhibitor. Major achievements were definition of the molecular mechanisms leading to this disease and the role of contact system activation and bradykinin formation. More recently contributed to development of new therapeutics for hereditary angioedema; identification and validation of disease biomarkers; creation of global disease registry for angioedema. He organized meetings to provide treatment guidelines for hereditary angioedema and the first classification of angioedema without wheals. He is president of the Medical Advisory Board of the Italian Association for Angioedema; co-chairman of the Medical Panel of the International Association for Hereditary Angioedema; chairman of the HAE Global Registry. Outside of hereditary angioedema, he provided original contributions to the understanding of the mechanisms leading to acquired deficiency of C1 inhibitor and associated lymphoproliferative diseases. He follows a case list of 24 patients with idiopathic systemic capillary leak syndrome (Clarkson Disease) and provided contributions to definition of the role of cytokines in this disease.
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Andrea Zanichelli,Mario Ghezzi, Ivan Santicchia,Romualdo Vacchini,Marco Cicardi,Antonella Sparaco,Girolamo Donati, Vito Ranìa, Alberto Busa
Francesca Perego,Antonio Gidaro,Andrea Zanichelli,Mauro Cancian,Francesco Arcoleo,Riccardo Senter,Maria Bova,Tiziana De Pasquale,Maria Domenica Guarino, Mariangela Lo Pizzo, Chiara Frigerio,Pier Giorgio Duca,
The Journal of Allergy and Clinical Immunology: In Practiceno. 5 (2020): 1772-1774
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