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个人简介
Prof. Dr. Maria Ines VACCARO, PhD, AGAF
Professor and Chair of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA) Buenos Aires, Argentina.
Principal Researcher & Pathophysiology Unit Leader at the Institute for Biochemistry and Molecular Medicine, National Council for Scientific Research (CONICET) Buenos Aires, Argentina.
ORCID identifier is 0000-0002-2456-747X
Scopus Author ID: 7005869334 - h-index: 22 - 4649 citations, 61 documents.
Research Interests:
The study of the molecular mechanisms that human cells trigger in response to disease is a very active area of scientific research in medicine. Our work is focused on the molecular mechanisms involved in the early events that occur in pancreatic cells during disease. In the search for new molecules that are differently expressed during acute pancreatitis, we cloned a new transmembrane protein called Vacuole Membrane Protein 1 (VMP1). In our laboratory, we discovered that VMP1 triggers autophagy in mammalian cells. Autophagy is a highly-preserved process in evolution whereby the cell degrades cytoplasmic components including organelles. Autophagy has been linked to a variety of pathological processes such as neurodegenerative diseases and tumorigenesis, which highlights its medical importance. We demonstrate that VMP1 mediates a new type of selective autophagy that acts as a defense mechanism in secreting cells. We also demonstrated that VMP1 participates in the mechanisms of resistance to death of pancreatic tumor cells and it is induced by hypoxia and chemotherapy. We showed that the interaction of VMP1 with specific plasma membrane proteins marks a new initiation site for autophagy and that the interaction of VMP1 with BH3 Domain of Beclin1 Is required for mammalian autophagy. Our present objective is to study the function of VMP1 in the initial steps of mammalian autophagy and the relevance of VMP1 expression as a cellular response to pathologies such as cancer, inflammatory bowel diseases, pancreatitis and diabetes. We believe that the study of the molecular mechanisms that cells are able to activate in the face of complex diseases will allow the developing of new and more rational therapeutic strategies.
Organization of scientific meetings and scientific societies:
-Council Member of the International Association of Pancreatology (2000-2008)
-Organizer of The LatinAmerican Pancreatic Study Group (LAPSG) and President 2004-2008 & 2014-2018
-Member of the Steering Committee for the Joint Meeting American Pancreatic Association - International Association of Pancreatology APA-IAP 2006
-President of the Club del Pancreas de la Republica Argentina 2008-2009.
-Member of the Abstract Selection Committee for the European Pancreatic Club (2009-2011).
-Member of the Abstract Selection Committee for the American Gastroenterology Association Institute for DDW2017 & DDW2018
-Organizer and Chair of the “Buenos Aires Conferences on Autophagy” (2011) Meetings 2011, 2013, 2015.
-President of the 21st International Association of Pancreatology Meeting, Buenos Aires, September 28-30, 2017.
-Member of the Advisory Program Committee for the EPC meeting 2019.
Editorial activity:
ASSOCIATE EDITOR OF PANCREATOLOGY, Elsevier (since 2011). EDITOR of Pancreatology Suppl Nov 2017. RESEARCH TOPIC EDITOR for Frontiers in Endocrinology. RESEARCH TOPIC ASSOCIATE EDITOR for Frontiers Cell and Developmental Biology. ASSOCIATE EDITOR of Journal of Translational Gastroenterology and of Clinical Hepatology and of World Journal of Gastroenterology (since 2009). EDITORIAL BOARD MEMBER of The Pancreapedia, University of Michigan Press (since 2010). MEMBER OF THE ADVISORY PANEL of Acta Gastroenterologica Latinoamericana (since 200). EDITOR IN CHIEF OF PHYSIOLOGICAL MINIREVIEWS (2009-2013). GUESS REVIEWER OF RESEARCH TOPIC for Frontiers in Endocrinology.
Main Awards:
-Awarded for the HONORABLE NATIONAL ACADEMY FOR MEDICINE (Bonorino Udaondo Prize, in 1995).
-Cherny Foundation Prize (2007).
-Argentine Society of Physiology Prize (2009).
-Argentine Society of Gastroenterology Prize (2006);
-Argentine Society of Gastroenterology Prize (2010),
-Awarded for the School of Medicine of the University of Buenos Aires (2011).
-Awarded for the HONORABLE NATIONAL ACADEMY FOR MEDICINE (Bonorino Udaondo Prize, in 2011).
-American Society for Biochemistry and Molecular Biology (ASBMB) (Paper of the week 2011)
Main Invited Conferences last five years:
-1st International Symposium on Autophagy, Phagositosis and Innate Immunity. 25-27 de enero, 2017. Salvador, Brasil. Conferencia tema: VMP1-Mediated Autophagy in Pancreatic Diseases.
-Reunion Conjunta de Sociedades de Biociencias, 13 al 17 de noviembre de 2017, Buenos Aires. Conferencia tema: Autophagy and Pancreas Diseases.
-ICGEB Workshop "Autophagy: Physiological and Pathological Roles” November 23th – 24th, 2016. Santiago-ˇChile. Conferencia tema: VMP1, a Pancreatitis Associated Protein, is Essential for Mammalian Autophagy
-Albert Einstein Medical Collage, New York, NY, USA. November 1, 2016. Conference entitle: Autophagy in Pancreas.
-23rd IUBMB Congress in Brazil at the city of Foz do Iguacu on 24th-28th August, 2015. Conference entitle: "Autophagy in Complex Diseases. The role of VMP1, a novel autophagy-related protein"
-1st PanAmerican Congress of Physiological Sciences (PanAm-2014), to be held in Iguassu Falls, Brazil, August 2-6. 2014. Keynote Lecture entitled “Authophagy in Pancreas Physiology and Diseases”
-Universidad de Antioquia, Medellin, Colombia. 11 de Octubre de 2013. Conferencia Tema: Autofagia.
-Congreso Argentino de Nutricion. Mar del Plata, 8 de Noviembre de 2013 Conferencia Tema: Autofagia.
-Digestive Disease Week 2013, Orlando USA, May 20, 2013. Session : Pancreatic Disorders Distinguished Abstract Plenary. The pancreatitis-associated protein VMP1 regulates autophagy induction through the interaction with the tumor suppressor protein Beclin 1.
Main International Project Cooperation
International Cooperation Program France-Argentina. 2001-2003. ANPCYT - ECOS-Sud. Directors: Vaccaro MI (Argentina); Patrice Codogno (France) 2015-2017
"Visiting Scientist" The Mayo Clinic Rochester. Invited by the director of the GI Research Unit, Rochester, Minnesota, USA. March-April 2001
International Cooperation Program France-Argentina. 2001-2003. ANPCYT - ECOS-Sud. Director A00S01. INSERM Unit315. Directors: Vaccaro MI (Argentina) and JL Iovanna (France).
Research Mentor
PhD
-Alejandro Ropolo, Expediente N° 735.900/01, Facultad de Farmacia y Bioquimica, UBA. Post grado Acreditado por CONEAU con Categoria A. Aprobada con calificacion 10 Sobresaliente, 29 de marzo de 2006.
-Romina Pardo, Lic. En Ciencias Biologicas, UBA. Facultad de Ciencias Exsactas y Naturales, UBA ResolucionNº1872 Fecha 04-08-2006. Post grado Acreditado por CONEAU con Categoria A. Aprobada con calificacion 10 Sobresaliente, 17 de marzo de 2009.
-Daniel Grasso, Bioquimico, UBA. Facultad de Farmacia y Bioquimica, UBA. Fecha 18-12-07 Exp. 709.323/07. Aprobada con calificacion 10 Sobresaliente con distincion “Summa cum laude” el 25 de abril de 2011.
-Maria Ines Molejon, Licenciada en Biologia, Beca Doctoral – Facultad de Farmacia y Bioquimica, UBA. Resolucion numero 47371/09. area de investigacion: Fisiopatologia. Aprobada con calificacion 10 Sobresaliente con distincion “Summa cum laude” el 2 de Octubre de 2013.
-Andrea Lo Re, Licenciada en Biotecnologia, UNQ. Doctorado en Biotecnologia, orientacion Genetica Molecular. Resolucion Comision de Doctorado de fecha 21 de Junio de 2007. Calificacion 10 Sobresaliente.
Master
-Gomez Auli, Alejandro. Medico. Universidad de Bogota Colombia. Tesis de Maestria Internacional, International Master Program in Biomedical Sciences, Argentina-Alemania. Facultad de Farmacia y Bioquimica, UBA. 2011. Calificacion Sobresaliente.
-Mariela Biondi. Bioquimica y Farmaceutica, Universidad Nacional de La Plata. Tesis de Maestria en Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Instituto de Investigaciones Bioquimicas, Universidad de Buenos Aires.
Post-Doc
-Alejandro Ropolo. CIC-CONICET, 2008-2015.
-Veronica Boggio, UBA, since 2007.
-Daniel Grasso, CIC-CONICET, since 2014
-Maria Noe Garcia, CIC-CONICET, since 2016
-Virginia Vanasco CIC-CONICET, since 2016
研究兴趣
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作者统计
#Papers: 129
#Citation: 3003
H-Index: 29
G-Index: 52
Sociability: 7
Diversity: 3
Activity: 22
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