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Sadelain and his team study gene transfer in hematopoietic stem cells and T cells, the regulation of transgene expression, the biology of chimeric antigen receptors, and therapeutic strategies to enhance immunity against cancer. Sadelain is a recognized leader in the conceptualization and design of synthetic receptors for antigen, which he named chimeric antigen receptors (CARs). T cells can be engineered to express a CAR to acquire the ability to recognize and destroy cancer cells. Sadelain has referred to CAR T cells as a “living drug.” A CAR typically comprises an antibody fragment (scFv) to recognize the cancer and a modular signaling domain to activate the T cell and promote T cell multiplication and persistence. CAR T cells are made by extracting a cancer patient’s T cells, inserting a CAR into the cell using a vector such as a gamma-retroviral or lentiviral vector, and then re-infusing the cells. Sadelain's current research makes use of genome editing, which he showed enhances CAR T cells when the CAR is expressed from the TRAC locus.
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Corina Amor, Inés Fernández-Maestre, Saria Chowdhury,Yu-Jui Ho,Sandeep Nadella, Courtenay Graham, Sebastian E. Carrasco, Emmanuella Nnuji-John,Judith Feucht, Clemens Hinterleitner, Valentin J. A. Barthet,Jacob A. Boyer,
Nature Agingno. 3 (2024): 336-349
Matthias. T. Stephan,Vladimir Ponomarev,Renier . J. Brentjens,Alex. H. Chang, Konstantin. Dobrenkov,Glenn Heller,Michel Sadelain
NATURE MEDICINE (2024)
Natureno. 8004 (2024): E9-E9
NATURE BIOTECHNOLOGYno. 4 (2024): 674-674
Nayan Jain,Zeguo Zhao,Richard P Koche, Chenling Antelope,Yosi Gozlan, Antonino Montalbano,David Brocks,Michael Lopez,Anton Dobrin,Yuzhe Shi,Gertrude Gunset,Theodoros Giavridis,
Yuzhe Shi, Ivan S. Kotchetkov,Anton Dobrin, Sophie A. Hanina,Vinagolu K. Rajasekhar,John H. Healey,Michel Sadelain
Molecular Therapy (2024)
Nature Cancerpp.1-14, (2024)
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