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个人简介
For several decades my laboratory has studied the molecular basis of cancer, in particular the genetic mutations that drive the evolution of cancer. In the recent decade our studies extend to the nature of human genome diversity and genetic mechanisms of devastating disorders such as autism and congenital heart disease. Common to all these subjects are a set of technologies, wet bench and computational, for comparing the genomes of cells and sifting through genomic distinctions for clues to genetic causation. We specifically are interested in copy number and point mutations, and using them for prognostication, early detection, and building models of medical disorders. Most recently we have added to our toolbox methods for examining the genomes and transcriptomes of single cells. Data-rich single cell methods have broad applications to describing neuronal complexity, cancer progression and host response, as well as a variety of fundamental problems of cell physiology.
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论文共 357 篇作者统计合作学者相似作者
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ADVANCED MATERIALS TECHNOLOGIESno. 2 (2024)
Joan Alexander,Jude Kendall, Jean McIndoo, Linda Rodgers,Robert Aboukhalil,Dan Levy,Asya Stepansky,Guoli Sun, Lubomir Chobardjiev, Michael Riggs, Hilary Cox,Inessa Hakker,
crossref(2023)
Joan Alexander,Jude Kendall, Jean McIndoo, Linda Rodgers,Robert Aboukhalil,Dan Levy,Asya Stepansky,Guoli Sun,Lubomir Chobardjiev, Michael Riggs, Hilary Cox,Inessa Hakker,
crossref(2023)
Joan Alexander,Jude Kendall, Jean McIndoo, Linda Rodgers,Robert Aboukhalil,Dan Levy,Asya Stepansky,Guoli Sun,Lubomir Chobardjiev, Michael Riggs, Hilary Cox,Inessa Hakker,
crossref(2023)
Koji Miyabayashi,Lindsey A. Baker,Astrid Deschênes, Benno Traub,Giuseppina Caligiuri,Dennis Plenker,Brinda Alagesan,Pascal Belleau,Siran Li,Jude Kendall,Gun Ho Jang, Risa Karakida Kawaguchi,
crossref(2023)
Joan Alexander,Jude Kendall, Jean McIndoo, Linda Rodgers,Robert Aboukhalil, Dan Levy,Asya Stepansky,Guoli Sun, Lubomir Chobardjiev,Michael Riggs, Hilary Cox,Inessa Hakker,
crossref(2023)
Siran Li,Joan Alexander,Jude Kendall,Peter Andrews, Elizabeth Rose, Hope Orjuela,Sarah Park, Craig Podszus, Liam Shanley,Rong Ma,Nissim Ranade,Michael Ronemus,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
openalex(2023)
openalex(2023)
Cell genomicsno. 6 (2023): 100319-100319
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