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The laboratory of Dr. Michalopoulos is investigating the mechanisms of liver regeneration and carcinogenesis in human and rodent liver. The studies focus on signaling from growth factors and cytokines that trigger the regenerative process. Other signals associated with integrins and extracellular matrix are involved in termination of hepatocyte proliferation, and many of these signals are deleted in human liver cancer. Most recent studies identified the liver growth factor receptors MET and EGFR as essential for liver regeneration, and for the transcriptional activation of hepatocyte proliferation genes. Augmentative hepatomegaly, induced by xenobiotic mitogens by compounds activating CAR, is also dependent on MET and EGFR for the associated proliferative response. Based on these studies, EGFR (but not MET) has been identified as a key regulator for hepatic lipid metabolism and in control of most transcription factors associated with NAFLD. The dramatic elimination and/or reversal of NAFLD associated with inhibition of EGFR opens the possibilities for pharmacologic management of NAFLD by using EGFR inhibitors already established in human pharmacology.
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论文共 648 篇作者统计合作学者相似作者
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Sowmya Mekala, Ravi Rai, Samantha Loretta Reed, Bill Bowen,George K Michalopoulos,Joseph Locker,Reben Raeman,Michael Oertel
Cellsno. 7 (2024)
Sowmya Mekala,Ravi Rai, Samantha Loretta Reed, Bill Bowen,George K. Michalopoulos,Joseph Locker,Reben Raeman,Michael Oertel
Cellsno. 7 (2024): 649
Sowmya Mekala,Ravi Rai, Samantha Loretta Reed, Bill Bowen,George K. Michalopoulos,Joseph Locker,Reben Raeman,Michael Oertel
CELLSno. 7 (2024)
Sowmya Mekala,Ravi Rai, Samantha Loretta Reed, Bill Bowen,George K. Michalopoulos,Joseph Locker,Reben Raeman,Michael Oertel
Shehnaz Bano, Matthew Avery Copeland,Anne Orr,Silvia Liu,Joseph Locker,John Stoops,Wendy M. Mars,George K. Michalopoulos,Bharat Bhushan
HEPATOLOGY (2023): S1087-S1087
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PloS oneno. 2 (2023): e0282358-e0282358
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