基本信息
浏览量:162
职业迁徙
个人简介
Specialty/Research Focus
Endocrinology; Inherited Metabolic Disorders; Metabolism; Molecular Basis of Disease; Neurobiology; Protein Function and Structure; Transgenic organisms
Professional Summary:
One research goal is to investigate the structure-function relationships and regulation of the human pyruvate dehydrogenase complex (PDC). We investigate the catalytic mechanism of the pyruvate dehydrogenase (PDH) component and its interactions with the dihydrolipoamide acetyltransferase (E2) component of PDC. We also determine the loci of interactions between PDH kinases (four PDK isoenzymes) and the lipoyl domains of E2.
Using a PDC-knockout mouse line we investigate the importance of glucose metabolism as a source of energy for brain development as well as the role of PDC in glucose-stimulated insulin secretion by pancreatic beta cells.
Another research goal is to investigate diet-induced metabolic programming during early life. We investigate (i) the effects of an altered nutrition during the immediate postnatal life on development of adult-onset obesity and (ii) the effects of maternal obesity on fetal programming. Current research focuses on the role of the hypothalamic signaling pathways in rodents with diet-induced obesity and also in the progeny of obese mothers.
研究兴趣
论文共 336 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Journal of developmental origins of health and diseaseno. 6 (2024): 711-718
Divya Choudhary, Gabriella A. Andreani,Saleh Mahmood,Xiaozhong Wen,Mulchand S. Patel,Todd C. Rideout
NUTRIENTSno. 7 (2024): 101004-101004
Translational Neuroscience Research and Reviewsno. 1 (2020)
Ilona Klejbor,Saleh Mahmood,Natalia Melka, Adriana Ebertowska,Janusz Morys,Ewa K Stachowiak,Michal K Stachowiak,Mulchand S Patel
Acta neurobiologiae experimentalisno. 3 (2020): 305-321
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn