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My group is focused on life-threatening fungal diseases. These infections pose difficulties in diagnosis, there are no vaccines for fungal disease, and treatment options are limited.
Fungal cells are surrounded by wall that is composed of signature molecules that are not represented at all in the human body. The cell wall is therefore the target which immune system uses to recognise the presence of a fungal invader and it is also an excellent target to aim the design of antifungal drugs.
For these reasons my group’s speciality is to understand how the fungal cell wall is made, how it is detected by our immune system and how we might kill fungi by blocking cell wall assembly. This research is therefore informing the design of new generations of antifungal drugs and diagnostic tests.
Fungal cells are surrounded by wall that is composed of signature molecules that are not represented at all in the human body. The cell wall is therefore the target which immune system uses to recognise the presence of a fungal invader and it is also an excellent target to aim the design of antifungal drugs.
For these reasons my group’s speciality is to understand how the fungal cell wall is made, how it is detected by our immune system and how we might kill fungi by blocking cell wall assembly. This research is therefore informing the design of new generations of antifungal drugs and diagnostic tests.
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The Journal of infectious diseases (2024)
Gabriela M Avelar,Arnab Pradhan,Qinxi Ma, Emer Hickey,Ian Leaves,Corin Liddle, Alejandra V Rodriguez Rondon,Ann-Kristin Kaune,Sophie Shaw,Corinne Maufrais,Natacha Sertour,Judith M Bain,
mBiono. 2 (2024): e0189823-e0189823
The Cell Surfacepp.100119, (2024)
JOURNAL OF INFECTIOUS DISEASES (2024)
Gabriela M. Avelar,Arnab Pradhan,Qinxi Ma, Emer Hickey,Ian Leaves,Corin Liddle, Alejandra V. Rodriguez Rondon,Ann-Kristin Kaune,Sophie Shaw,Corinne Maufrais,Natacha Sertour,Judith M. Bain,
MBIOno. 2 (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
The Cell Surface (2023): 100106-100106
The Cell Surface (2023): 100111-100111
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