基本信息
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职业迁徙
个人简介
Research Interests
Role of Tissue Factor in hemostasis, thrombosis and ischemia-reperfusion (I/R) injury
Research Synopsis
I am interested mechanisms of hemostasis and thrombosis, and the crosstalk between coagulation and inflammation. In particular, I study the role of tissue factor (TF), coagulation proteases, protease activated receptors (PARs) and microvesicles (MVs) in ischemia-reperfusion (I/R) injury, cancer, sickle cell disease, obesity, viral infection, atherosclerosis and liver injury. My lab has generated several unique mouse lines that have altered levels of TF, PAR1 and PAR2. For instance, we have made mice expressing only ~1% of wild-type TF levels. These mice have been used extensively by us and others to study the role of TF in hemostasis, thrombosis and other processes, such as inflammation in sickle cell disease. My lab also generated TF floxed mice that allows deletion of the TF gene in different cell types by crossing these mice with mice expressing the Cre recombinase in a cell type-specific manner.
研究兴趣
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Marisol Perez-Toledo,Nonantzin Beristain-Covarrubias,Jamie Pillaye,Ruby R Persaud,Edith Marcial-Juarez,Sian E. Jossi, Jessica R Hitchcock, Areej Alshayea, William M Channell,Rachel E Lamerton,Dean P Kavanagh,Agostina Carestia,
biorxiv(2024)
Thrombosis Research (2024): 155-162
Ana T. A. Sachetto,Nigel Mackman
FRONTIERS IN IMMUNOLOGY (2024)
Thrombosis Research (2024): 23-30
Yohei Hisada,Sierra J. Archibald, Karan Bansal,Yanjun Chen,Chen Dai, Sindhu Dwarampudi,Nora Balas,Lindsey Hageman,Nigel S. Key,Smita Bhatia,Ravi Bhatia,Nigel Mackman,
Journal of Thrombosis and Haemostasis (2024): 100596-100596
Yue Zhang,Vanthana Bharathi, Tatsuya Dokoshi,Jaime de Anda, Lauryn Tumey Ursery, Nikhil N. Kulkarni, Yoshiyuki Nakamura, Jonathan Chen, Elizabeth W. C. Luo, Lamei Wang,Hua Xu, Alison Coady,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 6 (2024): e2300644120-e2300644120
JOURNAL OF THROMBOSIS AND HAEMOSTASISno. 1 (2024): 3-6
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGYno. 3 (2024): 523-529
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