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Bile acid synthesis is the major metabolic pathway for the elimination of cholesterol. In addition to the pathway for bile acids that begins in the liver and is augmented with interruption of the enterohepatic circulation, a regulatory pathway has recently been discovered that begins with the production of 27-hydroxycholesterol in the aortic endothelium, macrophages, and other tissues. Our National Institutes of Health-funded research program is directed at the delineation of all the intermediates in the regulatory pathway and the determination of their biologic effects. We have already shown that 27-hydroxycholesterol is a potent inhibitor of cholesterol synthesis and LDL receptor activity. We are now investigating other biologic effects that may also occur.
A critical enzymatic step in the regulatory pathway is 7a-hydroxycholesterol which is catalyzed by a novel P-450 enzyme recently identified in our laboratory. This enzyme not only modifies the biologic effects of 27-hydroxycholesterol but also prevents the formation of monohydroxy bile acids which are known cholestatic agents. Thus, a second aspect of our research program is the metabolic basis of cholestatic liver disease.
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论文共 284 篇作者统计合作学者相似作者
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LIVER INTERNATIONALno. 9 (2023): 2046-2046
Journal of Crohn's and colitisno. 8 (2023): 1364-1368
Archives of Gastroenterology Research (2021)
Alana E O'Mara,James W Johnson,Joyce D Linderman,Robert J Brychta,Suzanne McGehee,Laura A Fletcher, Yael A Fink,Devika Kapuria,Thomas M Cassimatis,Nathan Kelsey,Cheryl Cero,Zahraa Abdul Sater,Francesca Piccinini,Alison S Baskin,Brooks P Leitner,Hongyi Cai,Corina M Millo,William Dieckmann,Mary Walter,Norman B Javitt,Yaron Rotman,Peter J Walter,Marilyn Ader,Richard N Bergman,Peter Herscovitch,Kong Y Chen,Aaron M Cypess
American journal of physiology Gastrointestinal and liver physiology/American journal of physiology Gastrointestinal and liver physiologyno. 5 (2020): G609-G618
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#Papers: 281
#Citation: 9274
H-Index: 51
G-Index: 87
Sociability: 6
Diversity: 0
Activity: 0
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