Akio Ohta
Principal Research Scientist
Behrakis Health Sciences Center
Northeastern University;New England Inflammation & Tissue Protection Institute, School of Pharmacy, Northeastern University;Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University;Department of Immunology, Foundation for Biomedical Research and Innovation at Kobe
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Research:
Regulation of immune/inflammatory responses
Inflammation plays important roles in a variety of human diseases. For example, allergic and autoimmune disorders are caused by uncontrolled inflammatory responses against exogenous and endogenous antigens, respectively. The lack of efficient immune responses against abnormal cells may lead to tumor progression. When infected to virus, strong anti-viral responses will be able to control the virus, but this may lead to severe tissue inflammation and serious tissue dysfunction as a result of massive elimination of virus-infected cells. On the other hand, insufficient anti-viral immune responses will allow persistent infection and repeated induction of inflammation and tissue remodeling (chronic inflammation) may result in fibrosis. Sepsis is life-threatening in two different ways: bacterial products induce strong systemic inflammatory responses which often causes septic shock, and following immune unresponsiveness loses control against infection.
Regulation of immune/inflammatory responses
Inflammation plays important roles in a variety of human diseases. For example, allergic and autoimmune disorders are caused by uncontrolled inflammatory responses against exogenous and endogenous antigens, respectively. The lack of efficient immune responses against abnormal cells may lead to tumor progression. When infected to virus, strong anti-viral responses will be able to control the virus, but this may lead to severe tissue inflammation and serious tissue dysfunction as a result of massive elimination of virus-infected cells. On the other hand, insufficient anti-viral immune responses will allow persistent infection and repeated induction of inflammation and tissue remodeling (chronic inflammation) may result in fibrosis. Sepsis is life-threatening in two different ways: bacterial products induce strong systemic inflammatory responses which often causes septic shock, and following immune unresponsiveness loses control against infection.
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Shengbin Ni,Shafiqur Rahman,Yasuhiro Harada, Shoji Yoshioka, Minami Imaizumi,Kuo H. Wong,Asami S. Mashio,Akio Ohta,Hiroshi Hasegawa
Chemosphere (2024): 140554-140554
Shafiqur Rahman, Makoto Saito, Shoji Yoshioka,Shengbin Ni,Kuo H. Wong,Asami S. Mashio,Zinnat A. Begum,Ismail M. M. Rahman,Akio Ohta,Hiroshi Hasegawa
Environmental Science and Pollution Researchno. 52 (2023): 112052-112070
Communications chemistryno. 1 (2023): 1-10
Shafiqur Rahman,Ismail M. M. Rahman,Shengbin Ni,Yasuhiro Harada,Shuto Kasai,Keisuke Nakakubo,Zinnat A. Begum, Kuo H. Wong, Asami S. Mashio,Akio Ohta,Hiroshi Hasegawa
Journal of Chromatography A (2021): 462476-462476
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