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个人简介
Pete Dedon’s research program applies chemical approaches to understanding nucleic acid biology in human disease. His research group has developed a variety of analytical and informatic platforms for discovery science in epigenetics and epitranscriptomics in infectious disease and cancer. One platform coordinates comparative genomics, single-molecule real-time sequencing, and mass spectrometry to discover novel epigenetic marks, such as the Dedon Lab’s recent discovery of phosphorothioate and 7-deazaguanine modifications in bacterial and bacteriophage genomes in the human microbiome. In the realm of epitranscriptomics, his team has applied systems-level analytics to discover a mechanism of translational control of cell response in eukaryotes and bacteria involving site-specific reprogramming of tRNAs and an alternative genetic code. Pete’s research groups at MIT and in Singapore are leveraging these discoveries to develop new enzymatic tools for biotechnology, new methods for industrial microbiology and protein production, and novel antimicrobial agents in screening- and structure-based drug discovery programs.
研究兴趣
论文共 361 篇作者统计合作学者相似作者
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Lulu Jiang, Rebecca Roberts,Melissa Wong,Lushuang Zhang, Chelsea Joy Webber, Jenna Libera, Zihan Wang, Alper Kilci, Matthew Jenkins, Alejandro Rondón Ortiz, Luke Dorrian,Jingjing Sun,
Frontiers in Neuroscience (2024)
Lulu Jiang, Rebecca Roberts,Melissa Wong,Lushuang Zhang, Chelsea Joy Webber, Jenna Libera, Zihan Wang, Alper Kilci, Matthew Jenkins, Alejandro Rondón Ortiz, Luke Dorrian,Jingjing Sun,
Frontiers in neuroscience (2024): 1372297-1372297
Sherif Rashad, Shadi Al-Mesitef, Abdulrahman Mousa, Yuan Zhou,Daisuke Ando,Guangxin Sun,Tomoko Fukuuchi, Yuko Iwasaki, Jingdong Xiang,Shane R Byrne,Jingjing Sun,Masamitsu Maekawa,
bioRxiv : the preprint server for biology (2024)
Journal of visualized experiments : JoVE (2024)
Sophie Giguère,Xuesong Wang,Sabrina Huber, Liling Xu,John Warner,Stephanie R Weldon,Jennifer Hu, Quynh Anh Phan, Katie Tumang, Thavaleak Prum,Duanduan Ma,Kathrin H Kirsch,
Science (New York, N.Y.)no. 6679 (2024): 205-211
Jun Yu Ip, Indrik Wijaya,Li Ting Lee, Yuhua Lim, Deryn En-Jie Teoh,Cheryl Siew Choo Chan,Liang Cui,Thomas J Begley,Peter C Dedon,Huili Guo
bioRxiv : the preprint server for biology (2024)
Shadi Al-Mesitef,Keita Tominaga, Abdulrahman Mousa,Thomas Begley,Peter Dedon,Sherif Rashad,Kuniyasu Niizuma
biorxiv(2024)
Samia Quaiyum, Yifeng Yuan,Guangxin Sun, R. M. Madhushi N. Ratnayake, Geoffrey Hutinet,Peter C. Dedon, Michael F. Minnick,Valérie de Crécy-Lagard
biorxiv(2024)
Frontiers in microbiology (2024): 1369018-1369018
Marshall Jaroch,Guangxin Sun,Ho-Ching Tiffany Tsui,Colbie Reed,Jingjing Sun, Marko Jörg, Malcolm E Winkler,Kelly C Rice,Agnieszka Dziergowska,Troy A Stich,Peter C Dedon,Patricia C Dos Santos,
Journal of bacteriologyno. 4 (2024): e0045223-e0045223
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