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个人简介
After a degree in Pharmacy at ULIEGE, I started my PhD in 2002 with Pr Alain Chariot (ULIEGE). My work focused on understanding molecular and cellular functions of Elongator, a six subunits complex (Elp1 to Elp6), which harbors an atypical acetyltransferase activity involved in cancer cells migration as well as in neuronal migration and development.
In 2006, I was awarded EMBO long-term postdoctoral fellow and I joined the lab of Pr Jesper Svejstrup at London Research Institute - Cancer Research UK, with the ambition to establish connections between gene transcription - mRNA biology and proteome expression. We biochemically purified nascent, chromatin-associated mRNP particles and we identified a novel proteins that act at the interface between mRNP particles and RNAPII, integrating transcript elongation to alternative splicing and proteome expression.
Since 2013, I established my lab at the GIGA-Institute in Liege. Our work focuses on understanding the mechanisms underlying cancer development through changes in proteome expression and mRNA translation via tRNA regulation. We combine classical biochemistry, high throughput sequencing technologies to in vivo models of cancer, and patient-derived materials. We aim to uncover crucial regulation mechanisms supporting cancer cell adaptation and rewiring during disease progression. We recently uncovered the importance of wobble uridine tRNA modification enzymes in tumor initiation, metastasis6 and drug resistance. We found that wobble tRNA modification enzymes induce a codon-specific translation reprogramming and promote resistance to targeted therapies in melanoma, suggesting that they may represent new therapeutic targets in cancer. Our future work is dedicated to the study of tRNA regulation in cancer biology.
In 2006, I was awarded EMBO long-term postdoctoral fellow and I joined the lab of Pr Jesper Svejstrup at London Research Institute - Cancer Research UK, with the ambition to establish connections between gene transcription - mRNA biology and proteome expression. We biochemically purified nascent, chromatin-associated mRNP particles and we identified a novel proteins that act at the interface between mRNP particles and RNAPII, integrating transcript elongation to alternative splicing and proteome expression.
Since 2013, I established my lab at the GIGA-Institute in Liege. Our work focuses on understanding the mechanisms underlying cancer development through changes in proteome expression and mRNA translation via tRNA regulation. We combine classical biochemistry, high throughput sequencing technologies to in vivo models of cancer, and patient-derived materials. We aim to uncover crucial regulation mechanisms supporting cancer cell adaptation and rewiring during disease progression. We recently uncovered the importance of wobble uridine tRNA modification enzymes in tumor initiation, metastasis6 and drug resistance. We found that wobble tRNA modification enzymes induce a codon-specific translation reprogramming and promote resistance to targeted therapies in melanoma, suggesting that they may represent new therapeutic targets in cancer. Our future work is dedicated to the study of tRNA regulation in cancer biology.
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论文共 91 篇作者统计合作学者相似作者
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HemaSphereno. S3 (2023): e52627ab-e52627ab
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Blood (2023)
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Hong Quan Duong,Ivan Nemazanyy,Florian Rambow, Seng Chuan Tang,Sylvain Delaunay,Lars Tharun,Alexandra Florin,Reinhard Büttner, Daniel Vandaele,Pierre Close,Jean-Christophe Marine,Kateryna Shostak,
crossref(2023)
crossref(2023)
Hong Quan Duong,Ivan Nemazanyy,Florian Rambow, Seng Chuan Tang,Sylvain Delaunay,Lars Tharun,Alexandra Florin,Reinhard Büttner, Daniel Vandaele,Pierre Close,Jean-Christophe Marine,Kateryna Shostak,
crossref(2023)
user-5fe1a78c4c775e6ec07359f9(2022)
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