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个人简介
Our research focuses on the physiological, pharmacological and anatomical bases of synaptic transmission, with a particular emphasis on cellular substrates of pathological conditions in the Central Nervous System (CNS). Our recent work focuses on three main themes:
synaptic mechanisms in the sensory spinal cord and their plasticity during development and in experimental models of chronic pain;
synaptic changes in the neocortex during ageing and Alzheimer’s disease;
the impact of synaptic activity on the computational properties of neurons.
We use a wide array of approaches, including electrophysiological recording in vivo (micro-optrodes) and in vitro (patch clamp in slices), multiphoton and other non-linear imaging techniques, time-resolved fluorescence microscopy, in vivo optogenetics, tissue-based biochemical analysis, neural tracing and immunocytochemistry, and computational approaches.
synaptic mechanisms in the sensory spinal cord and their plasticity during development and in experimental models of chronic pain;
synaptic changes in the neocortex during ageing and Alzheimer’s disease;
the impact of synaptic activity on the computational properties of neurons.
We use a wide array of approaches, including electrophysiological recording in vivo (micro-optrodes) and in vitro (patch clamp in slices), multiphoton and other non-linear imaging techniques, time-resolved fluorescence microscopy, in vivo optogenetics, tissue-based biochemical analysis, neural tracing and immunocytochemistry, and computational approaches.
研究兴趣
论文共 261 篇作者统计合作学者相似作者
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Neurophotonicsno. 1 (2024): 014401-014401
Painno. 6 (2024): 1304-1316
JOURNAL OF PHYSICAL CHEMISTRY Cno. 15 (2024): 6357-6369
SURFACES AND INTERFACES (2024): 103647
Orisson P. Gomes,Sanggon Kim, Paulo N. Lisboa-Filho,Augusto Batagin-Neto,Yves De Koninck,Younes Messaddeq
JOURNAL OF MATERIALS CHEMISTRY C (2024)
C. Sahara Khademullah, Julien Bourbonnais,Mathilde M. Chaineau,María José Castellanos-Montiel,Iason Keramidis, Alexandra Legault,Marie-Ève Paquet,Agessandro Abrahao,Lorne Zinman,Janice Robertson,Thomas M. Durcan,Melanie A. Woodin,
biorxiv(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiquesno. 1 (2023): 96-98
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