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个人简介
My laboratory works on understanding the mechanisms by which cells sense and signal hypoxia (low oxygen levels). Oxygen is of fundamental importance for most living organisms, and the maintenance of oxygen homeostasis is a central physiological challenge for all large animals. Hypoxia is an important component of many human diseases including cancer, heart disease, stroke, vascular disease, and anaemia.
Working initially on regulation of the haematopoietic growth factor erythropoietin (which shows strong transcriptional upregulation by hypoxia), the laboratory discovered that the underlying oxygen sensitive signal pathway is widely operative in mammalian cells, extends to invertebrates, and mediates a range of other transcriptional responses including those regulating angiogenesis and metabolism. The laboratory went to define the oxygen sensing and signalling pathways that link the essential transcription factor, hypoxia inducible factor (HIF) to the availability of oxygen.
Working initially on regulation of the haematopoietic growth factor erythropoietin (which shows strong transcriptional upregulation by hypoxia), the laboratory discovered that the underlying oxygen sensitive signal pathway is widely operative in mammalian cells, extends to invertebrates, and mediates a range of other transcriptional responses including those regulating angiogenesis and metabolism. The laboratory went to define the oxygen sensing and signalling pathways that link the essential transcription factor, hypoxia inducible factor (HIF) to the availability of oxygen.
研究兴趣
论文共 504 篇作者统计合作学者相似作者
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Cancer researchno. 11 (2024): 1799-1816
Jingyi Ma,Khatoun Al Moussawi,Hantao Lou, Hok Fung Chan,Yihua Wang,Joseph Chadwick,Chansavath Phetsouphanh,Elizabeth A. Slee,Shan Zhong,Thomas M. Leissing,Andrew Roth,Xiao Qin, Shuo Chen, Jie Yin,Indrika Ratnayaka, Yang Hu,Pakavarin Louphrasitthiphol,Lewis Taylor,Paulo J. G. Bettencourt, Mary Muers,David R. Greaves,Helen Mcshane,Robert Goldin,Elizabeth J. Soilleux,Mathew L. Coleman,Peter J. Ratcliffe,Xin Lu
Proceedings of the National Academy of Sciences of the United States of Americano. 10 (2024)
crossref(2024)
crossref(2024)
Cancer Researchno. 6_Supplement (2024): 6622-6622
openalex(2024)
Cancer Researchno. 6_Supplement (2024): 6944-6944
Karen C. Heathcote,Thomas P. Keeley,Matti Myllykoski, Malin Lundekvam,Nina McTiernan, Salma Akter,Norma Masson,Peter J. Ratcliffe,Thomas Arnesen,Emily Flashman
Nature communicationsno. 1 (2024)
openalex(2024)
Maria Prange-Barczynska, Holly A Jones,Yoichiro Sugimoto,Xiaotong Cheng, Joanna Dcc Lima,Indrika Ratnayaka,Gillian Douglas,Keith J Buckler,Peter J Ratcliffe, Thomas P Keeley,Tammie Bishop
The Journal of clinical investigationno. 18 (2024)
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#Papers: 500
#Citation: 95845
H-Index: 124
G-Index: 308
Sociability: 8
Diversity: 0
Activity: 1
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