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My research group works with both state of the art computer simulations and experimental protein engineering to understand life at the atomistic level. Enzymes are natural biocatalysts that are essential for the living cell. This is perhaps well illustrated by the fact that fundamental and organizational tasks, for instance energy generation and information processing, would take millions - or even billion - of years in the absence of biocatalysts, which represent timescales that would be incompatible with life.
Enzyme catalysis evolved in an aqueous environment and water constitutes a cornerstone for the chemistry of life. Our research aims for an enhanced understanding of the impact of solvent dynamics on enzyme catalysis and motion which is currently poorly understood and usually neglected.Towards reaching this goal we bridge fundamental chemical principles with biotechnology. Through transdisciplinary scientific methods we are developing novel enzyme engineering strategies for applications within biopolymer science and for the sustainable generation of fine chemicals from renewable sources.
研究兴趣
论文共 68 篇作者统计合作学者相似作者
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crossref(2024)
crossref(2024)
Methods in Enzymology (2024)
biorxiv(2023)
Nature Communicationsno. 1 (2023): 1-14
Research Square (Research Square) (2023)
David Hueting,Karen Schriever, Rui Sun,Stelios Vlachiotis,Fanglei Zuo,Likun Du,Helena Persson, Camilla Hofstrom,Mats Ohlin,Karin Wallden,Marcus Buggert,Lennart Hammarstrom,
NATURE COMMUNICATIONSno. 1 (2023)
ACS SUSTAINABLE CHEMISTRY & ENGINEERINGno. 8 (2023): 3451-3465
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