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Academic Focus
Cancer prevention, tumor microenvironment, inflammation and cancer
colorectal cancer biology, early disease progression
Intestinal epithelial biology, cancer stem cell biology, cancer interception
Dr. DuBois is an internationally renowned expert and is known for his work elucidating the role of inflammation and inflammatory mediators in the progression of colon cancer. His laboratory examines the molecular mechanisms by which inflammatory mediators affect epithelial biology, the tumor microenvironment and cancerization. In the 1990s, DuBois and colleagues made the landmark discovery that colorectal tumors contained high levels of a key enzyme (COX-2) which regulates prostaglandin production. COX-2 catalyzes a key step in the production of pro-inflammatory mediators leading to the production of prostaglandin E2 (PGE2). This work and other studies unveiled a better understanding of the role of anti-inflammatory agents, like aspirin, in reducing cancer risk which led to clinical trials, showing how drugs that inhibit this pathway could prevent or intercept the process of cancer development early on. More recent studies have revealed that PGE2 regulates the immune status of the tumor microenvironment and inhibitors of PGE2 signaling block tumor metastasis and cancer progression.
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论文共 356 篇作者统计合作学者相似作者
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CANCER RESEARCH COMMUNICATIONSno. 8 (2023): 1486-1500
Lisa A DuBois,Raymond N DuBois
Regular and Young Investigator Award Abstracts (2022)
David Jay Wilson,Raymond N. DuBois
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作者统计
#Papers: 362
#Citation: 50528
H-Index: 106
G-Index: 223
Sociability: 7
Diversity: 3
Activity: 27
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