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个人简介
My research focuses on the mechanism of hepatic fibrosis.
Liver fibrosis results from the deposition of excess, abnormal extracellular matrix by myofibroblasts derived from non-fibrogenic cells that undergo “activation” in the context of chronic liver injury. Fibrosis in the bile duct is a similar matrix-driven process, although the identity of the myofibroblast populations and the chronic vs. acute nature of the injury are not known.
We are investigating the mechanisms of fibrosis in three ways: a) by studying the matrix, mechanical, and soluble factors that influence fibrosis, including the activation of myofibroblast precursor populations; b) by identifying new fibrogenic cell populations and new means of studying previously identified cells; and c) by applying the results of our experiments with isolated cells to whole animal models and to the study of human diseases, including hepatocellular carcinoma and biliary fibrosis.
研究兴趣
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Kapish Gupta,Jimmy P. Xu,Tamir Diamond, Iris E. M. de Jong, Andrew Glass,Jessica Llewellyn,Neil D. Theise,Orith Waisbourd-Zinman, Jeffrey D. Winkler,Edward M. Behrens,Clementina Mesaros,Rebecca G. Wells
Iris E. M. de Jong,Rebecca G. Wells
Pediatric and Developmental Pathologypp.10935266241247479-10935266241247479, (2024)
BIOFABRICATIONno. 1 (2024)
Fitzroy J Byfield, Behnaz Eftekhari, Kaeli Kaymak-Loveless,Kalpana Mandal,David Li,Rebecca G Wells, Wenjun Chen,Jasna Brujic, Guilia Bergamaschi, Gijs J L Wuite,Alison E Patteson,Paul A Janmey
bioRxiv : the preprint server for biology (2024)
Weiguo Fan,Kolade Adebowale,Lóránd Váncza,Yuan Li, Md Foysal Rabbi,Koshi Kunimoto,Dongning Chen,Gergely Mozes,David Kung-Chun Chiu, Yisi Li,Junyan Tao,Yi Wei,
Natureno. 7999 (2024): 635-642
Christopher W. Wasson, Enrico De Lorenzis,Eva M. Clavane,Rebecca L. Ross, Kieran A. Walker,Begoña Caballero-Ruiz,Cristina Antinozzi,Rebecca Wells, Gemma Migneco,Jane M.Y. Brown, Samuel J. Turvey, Katie J. Simmons,
Journal of Investigative Dermatology (2024)
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