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个人简介
My research focuses on the genetic basis and developmental mechanisms of congenital structural anomalies, particularly craniofacial developmental disorders, including cleft lip, cleft palate, frontonasal dysplasia, midfacial hypoplasia, micrognathia and missing or supernumerary teeth. We work to understand the causes and developmental mechanisms of congenital defects to improve diagnosis, treatment and patient care.
I majored in biology in college and actively conducted undergraduate research. I was fascinated by the processes of cell differentiation and received a master's degree in Genetics from the Chinese Academy of Science. Then I came to the United States for doctorate training in developmental biology.
Although my research projects during graduate and postdoctoral training mostly focused on uncovering basic cellular and molecular mechanisms of embryonic development, the results had clear applications in understanding pathogenic mechanisms of human developmental disorders. I decided to pursue an independent academic research career focused on understanding the genetic basis and developmental mechanisms of major structural birth defects.
More than 3 percent of children are born with developmental defects. Many of these children have defects in craniofacial structures that require surgical treatment shortly after birth. The causes and pathogenic mechanisms of most craniofacial congenital anomalies are not well understood. Our research aims to gain a comprehensive understanding of the cellular and molecular mechanisms of craniofacial development and provide solid scientific knowledge for the development and improvement of strategies for diagnosis, treatment and clinical care of children with such developmental disorders.
I majored in biology in college and actively conducted undergraduate research. I was fascinated by the processes of cell differentiation and received a master's degree in Genetics from the Chinese Academy of Science. Then I came to the United States for doctorate training in developmental biology.
Although my research projects during graduate and postdoctoral training mostly focused on uncovering basic cellular and molecular mechanisms of embryonic development, the results had clear applications in understanding pathogenic mechanisms of human developmental disorders. I decided to pursue an independent academic research career focused on understanding the genetic basis and developmental mechanisms of major structural birth defects.
More than 3 percent of children are born with developmental defects. Many of these children have defects in craniofacial structures that require surgical treatment shortly after birth. The causes and pathogenic mechanisms of most craniofacial congenital anomalies are not well understood. Our research aims to gain a comprehensive understanding of the cellular and molecular mechanisms of craniofacial development and provide solid scientific knowledge for the development and improvement of strategies for diagnosis, treatment and clinical care of children with such developmental disorders.
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Alison J Perl,Han Liu,Matthew Hass, Nirpesh Adhikari,Praneet Chaturvedi,Yueh-Chiang Hu,Rulang Jiang, Yaping Liu,Raphael Kopan
Journal of the American Society of Nephrology : JASNno. 5 (2024): 566-577
DEVELOPMENTAL DYNAMICS (2024)
Adriana Lofrano-Porto,Sidney Alcântara Pereira,Andrew Dauber, Jordana Cb Bloom, Audrey N Fontes,Naomi Asimow, Olívia Laquis de Moraes, Petra Ariadne T Araujo,Ana Paula Abreu,Michael H Guo,Silviene F De Oliveira,Han Liu,
The Journal of clinical investigation (2023)
Developmental biology (2023): 1-9
Lin Liu,Yi Zhou, Zhimin Liu,Jiangyuan Li,Linghao Hu,Leya He,Guannan Gao, Brian Kidd, Alexandra Walsh,Rulang Jiang,Chaodong Wu,Ke Zhang,
Cellular and Molecular Gastroenterology and Hepatologyno. 5 (2023): 1117-1133
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PLoS geneticsno. 6 (2023)
Adriana Lofrano-Porto,Sidney Alcantara Pereira,Andrew Dauber, Jordana C. B. Bloom, Audrey N. Fontes,Naomi Asimow, Olivia Laquis de Moraes, Petra Ariadne T. Araujo,Ana Paula Abreu,Michael H. Guo,Silviene F. De Oliveira,Han Liu,
JOURNAL OF CLINICAL INVESTIGATIONno. 23 (2023)
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