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Over the past 25 years, the research group directed by Dr. Paul Ridker has been collaboratively responsible for elucidating the critical role of inflammation in the detection, prevention, and treatment of cardiovascular diseases. This work has proven the inflammation hypothesis of atherosclerosis, led to guideline endorsed use of inflammatory biomarkers in clinical practice, widely expanded the indications for statin therapy in prevention, and resulted in the development of several entirely novel therapeutics for both heart disease and cancer.
Best known for his pioneering population biology work on inflammatory biomarkers such as high-sensitivity CRP and interleukin-6 (1997), the first demonstration of the anti-inflammatory effects of statins (1998), the guideline changing JUPITER trial (2008), and ultimately through the CANTOS interleukin-1b inhibition trial (2017) and the CIRT low-dose methotrexate trial (2019), Dr. Ridker’s work has led to a fundamental shift in our understanding of atherosclerosis and to the first proof-of-principle that targeted anti-cytokine therapies can lower cardiovascular event rates in the absence of lipid lowering. Insights from his group that the magnitude of inflammation inhibition directly relates to the magnitude of clinical benefit has spawned a novel class of cardiovascular therapeutics and led to the clinical recognition that “residual inflammatory risk” is a separate and distinct entity from “residual cholesterol risk”. Moreover, in simultaneous work related to inflammation in the tumor microenvironment, Dr. Ridker demonstrated for the first time that interleukin-1b inhibition dramatically lowers lung cancer mortality (2017), work that has additionally opened an entirely novel approach to the treatment of inflammatory cancers.
Best known for his pioneering population biology work on inflammatory biomarkers such as high-sensitivity CRP and interleukin-6 (1997), the first demonstration of the anti-inflammatory effects of statins (1998), the guideline changing JUPITER trial (2008), and ultimately through the CANTOS interleukin-1b inhibition trial (2017) and the CIRT low-dose methotrexate trial (2019), Dr. Ridker’s work has led to a fundamental shift in our understanding of atherosclerosis and to the first proof-of-principle that targeted anti-cytokine therapies can lower cardiovascular event rates in the absence of lipid lowering. Insights from his group that the magnitude of inflammation inhibition directly relates to the magnitude of clinical benefit has spawned a novel class of cardiovascular therapeutics and led to the clinical recognition that “residual inflammatory risk” is a separate and distinct entity from “residual cholesterol risk”. Moreover, in simultaneous work related to inflammation in the tumor microenvironment, Dr. Ridker demonstrated for the first time that interleukin-1b inhibition dramatically lowers lung cancer mortality (2017), work that has additionally opened an entirely novel approach to the treatment of inflammatory cancers.
研究兴趣
论文共 1615 篇作者统计合作学者相似作者
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Arthritis Research & Therapyno. 1 (2024): 1-9
Markus Scholz,Katrin Horn,Janne Pott,Matthias Wuttke,Andreas Kühnapfel, M. Kamal Nasr,Holger Kirsten,Yong Li,Anselm Hoppmann,Mathias Gorski,Sahar Ghasemi,Man Li,Adrienne Tin,Jin-Fang Chai,Massimiliano Cocca,Judy Wang,Teresa Nutile,Masato Akiyama,Bjørn Olav Åsvold,Nisha Bansal,Mary L. Biggs,Thibaud Boutin,Hermann Brenner,Ben Brumpton,Ralph Burkhardt,Jianwen Cai,Archie Campbell,Harry Campbell,John Chalmers,Daniel I. Chasman,Miao Ling Chee,Miao Li Chee,Xu Chen,Ching-Yu Cheng,Renata Cifkova,Martha Daviglus,Graciela Delgado,Katalin Dittrich,Todd L. Edwards,Karlhans Endlich,J. Michael Gaziano,Ayush Giri,Franco Giulianini,Scott D. Gordon,Daniel F. Gudbjartsson,Stein Hallan,Pavel Hamet,Catharina A. Hartman,Caroline Hayward,Iris M. Heid,Jacklyn N. Hellwege,Bernd Holleczek,Hilma Holm,Nina Hutri-Kähönen,Kristian Hveem,Berend Isermann,Jost B. Jonas,Peter K. Joshi,Yoichiro Kamatani,Masahiro Kanai,Mika Kastarinen,Chiea Chuen Khor,Wieland Kiess,Marcus E. Kleber,Antje Körner,Peter Kovacs,Alena Krajcoviechova,Holly Kramer,Bernhard K. Krämer,Mikko Kuokkanen,Mika Kähönen,Leslie A. Lange,James P. Lash,Terho Lehtimäki,Hengtong Li,Bridget M. Lin,Jianjun Liu,Markus Loeffler,Leo-Pekka Lyytikäinen,Patrik K. E. Magnusson,Nicholas G. Martin,Koichi Matsuda,Yuri Milaneschi,Pashupati P. Mishra,Nina Mononen,Grant W. Montgomery,Dennis O. Mook-Kanamori,Josyf C. Mychaleckyj,Winfried März,Matthias Nauck,Kjell Nikus,Ilja M. Nolte,Raymond Noordam, Yukinori Okada,Isleifur Olafsson,Albertine J. Oldehinkel,Brenda W. J. H. Penninx,Markus Perola,Nicola Pirastu,Ozren Polasek,David J. Porteous,Tanja Poulain,Bruce M. Psaty,Ton J. Rabelink,Laura M. Raffield,Olli T. Raitakari,Humaira Rasheed,Dermot F. Reilly,Kenneth M. Rice,Anne Richmond,Paul M. Ridker,Jerome I. Rotter,Igor Rudan,Charumathi Sabanayagam,Veikko Salomaa,Neil Schneiderman,Ben Schöttker,Mario Sims,Harold Snieder,Klaus J. Stark,Kari Stefansson,Hannah Stocker,Michael Stumvoll,Patrick Sulem,Gardar Sveinbjornsson,Per O. Svensson,E-Shyong Tai,Kent D. Taylor,Bamidele O. Tayo,Andrej Teren,Yih-Chung Tham,Joachim Thiery,Chris H. L. Thio,Laurent F. Thomas,Johanne Tremblay,Anke Tönjes,Peter J. van der Most,Veronique Vitart,Uwe Völker,Ya Xing Wang,Chaolong Wang,Wen Bin Wei,John B. Whitfield,Sarah H. Wild,James F. Wilson,Thomas W. Winkler,Tien-Yin Wong,Mark Woodward,Xueling Sim,Audrey Y. Chu,Mary F. Feitosa,Unnur Thorsteinsdottir,Adriana M. Hung,Alexander Teumer,Nora Franceschini,Afshin Parsa,Anna Köttgen,Pascal Schlosser,Cristian Pattaro
Nature Communicationsno. 1 (2024): 1-17
European journal of internal medicine (2024)
Lucas L. Marinho,Brendan M. Everett, Aaron W. Aday, Frank L. J. Visseren,Jean G. MacFadyen,Elaine Zaharris,Jorge Plutzky,Raul D. Santos,Peter Libby,Jean -Charles Fruchart,Paul M. Ridker,Aruna Das Pradhan
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGYno. 4 (2024): 408-410
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGYno. 7 (2024): e196-e206
Rosalie B. T. M. Sterenborg,Inga Steinbrenner,Yong Li, Melissa N. Bujnis,Tatsuhiko Naito,Eirini Marouli,Tessel E. Galesloot,Oladapo Babajide,Laura Andreasen,Arne Astrup,Bjørn Olav Åsvold,Stefania Bandinelli,Marian Beekman,John P. Beilby,Jette Bork-Jensen,Thibaud Boutin,Jennifer A. Brody,Suzanne J. Brown,Ben Brumpton,Purdey J. Campbell,Anne R. Cappola,Graziano Ceresini,Layal Chaker,Daniel I. Chasman,Maria Pina Concas,Rodrigo Coutinho de Almeida,Simone M. Cross,Francesco Cucca,Ian J. Deary,Alisa Devedzic Kjaergaard,Justin B. Echouffo Tcheugui,Christina Ellervik,Johan G. Eriksson,Luigi Ferrucci,Jan Freudenberg,Christian Fuchsberger,Christian Gieger,Franco Giulianini,Martin Gögele,Sarah E. Graham,Niels Grarup,Ivana Gunjača,Torben Hansen,Barbara N. Harding,Sarah E. Harris,Stig Haunsø,Caroline Hayward,Jennie Hui,Till Ittermann,J. Wouter Jukema,Eero Kajantie,Jørgen K. Kanters,Line L. Kårhus,Lambertus A. L. M. Kiemeney,Margreet Kloppenburg,Brigitte Kühnel,Jari Lahti,Claudia Langenberg,Bruno Lapauw,Graham Leese,Shuo Li,David C. M. Liewald,Allan Linneberg,Jesus V. T. Lominchar,Jian’an Luan,Nicholas G. Martin,Antonela Matana,Marcel E. Meima,Thomas Meitinger,Ingrid Meulenbelt,Braxton D. Mitchell,Line T. Møllehave,Samia Mora,Silvia Naitza,Matthias Nauck,Romana T. Netea-Maier,Raymond Noordam,Casia Nursyifa,Yukinori Okada,Stefano Onano,Areti Papadopoulou,Colin N. A. Palmer,Cristian Pattaro,Oluf Pedersen,Annette Peters,Maik Pietzner,Ozren Polašek,Peter P. Pramstaller,Bruce M. Psaty,Ante Punda,Debashree Ray,Paul Redmond,J. Brent Richards,Paul M. Ridker,Tom C. Russ,Kathleen A. Ryan,Morten Salling Olesen,Ulla T. Schultheiss,Elizabeth Selvin,Moneeza K. Siddiqui,Carlo Sidore,P. Eline Slagboom,Thorkild I. A. Sørensen,Enrique Soto-Pedre,Tim D. Spector,Beatrice Spedicati,Sundararajan Srinivasan,John M. Starr,David J. Stott,Toshiko Tanaka,Vesela Torlak,Stella Trompet,Johanna Tuhkanen,André G. Uitterlinden,Erik B. van den Akker, Tibbert van den Eynde,Melanie M. van der Klauw,Diana van Heemst,Charlotte Verroken,W. Edward Visser,Dina Vojinovic,Henry Völzke,Melanie Waldenberger,John P. Walsh,Nicholas J. Wareham,Stefan Weiss,Cristen J. Willer,Scott G. Wilson,Bruce H. R. Wolffenbuttel,Hanneke J. C. M. Wouters,Margaret J. Wright,Qiong Yang,Tatijana Zemunik,Wei Zhou,Gu Zhu,Sebastian Zöllner,Johannes W. A. Smit,Robin P. Peeters,Anna Köttgen,Alexander Teumer,Marco Medici
Nature communicationsno. 1 (2024)
Lucas L. Marinho,Brendan M. Everett, Aaron W. Aday, Frank L.J. Visseren,Jean G. MacFadyen,Elaine Zaharris,Jorge Plutzky,Raul D. Santos,Peter Libby,Jean-Charles Fruchart,Paul M Ridker,Aruna Das Pradhan
Journal of the American College of Cardiologyno. 4 (2024): 408-410
Steven E. Nissen,Howard G. Hutchinson,Kathy Wolski,Karol Watson,Seth S. Martin,Erin D. Michos, William S. Weintraub, Melanie Morris,Leslie Cho,Luke Laffin,Douglas Jacoby,Christie M. Ballantyne, Jan Ekelund,Filip Birve,Venu Menon, Michelle Strzelecki,Paul M. Ridker
Atherosclerosis (2024): 117835
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作者统计
#Papers: 1608
#Citation: 286436
H-Index: 242
G-Index: 516
Sociability: 10
Diversity: 0
Activity: 6
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