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职业迁徙
个人简介
My research focusses on the function of the PKD1 gene family. Mutations in PKD1 cause autosomal dominant polycystic kidney disease (ADPKD). PKD1 encodes polycystin-1, a large cell-surface protein of unknown function. Using biochemical, molecular and structural techniques we aim to identify extracellular and intracellular ligands and show how they interact with protein domains found in polycystin-1. In addition, mechanisms that target polycystin-1 to the cell surface are being identified. The polycystins have been shown to function as mechanosensitive calcium channels localised to the renal primary cilium. We have shown that members of the classical receptor protein tyrosine phosphatase family interact with the polycystins in the primary cilium. This identifies a novel mechanism for mechanoregulation of ion channel function. Elucidation of the normal function of polycystin-1 will identify key steps in the pathogenesis of ADPKD and potential ways of modifying disease progression.
研究兴趣
论文共 181 篇作者统计合作学者相似作者
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Omid Sadeghi-Alavijeh,Melanie MY Chan, Gabriel Doctor, Catalin Voinescu,Alex Stuckey, Athanasios Kousathanas, Alexander Ho,Horia Stanescu,Detlef Bockenhauer,Richard Sandford,Adam P Levine,Daniel P Gale
crossref(2024)
Journal of Clinical Investigation (2024)
medrxiv(2024)
GUTno. SUPPL_3 (2023): A32-A33
HEPATOLOGY COMMUNICATIONSno. 4 (2023)
NEPHROLOGY (2023): 39-39
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Laura Martinez-Gili,Alexandros Pechlivanis,Julie A K McDonald,Sofina Begum,Jonathan Badrock,Jessica K Dyson,Rebecca Jones,Gideon Hirschfield,Stephen D Ryder,Richard Sandford,Simon Rushbrook,Douglas Thorburn,Simon D Taylor-Robinson,Mary M E Crossey,Julian R Marchesi,George Mells,Elaine Holmes,David Jones
Heather J. Cordell, James J. Fryett,Kazuko Ueno,Rebecca Darlay,Yoshihiro Aiba.,Yuki Hitomi., Minae. Kawashima, Nao Nishida,Seik-Soon Khor, Olivier Gervais,Yosuke Kawai,Masao Nagasaki,Katsushi Tokunaga,Ruqi Tang,Yongyong Shi,Zhiqiang Li,Brian D. Juran,Elizabeth J. Atkinson,Alessio Gerussi, Marco Carbone, Rosanna Asselta,Angela Cheung, Mariza de Andrade,Aris Baras, Julie Horowitz, Manuel A. R. Ferreira,Dylan Sun,David E. Jones,Steven Flack,Ann Spicer,Victoria L. Mulcahy, Jinyoung Byan,Younghun Han,Richard N. Sandford,Konstantinos N. Lazaridis, Christopher I. Amos,Gideon M. Hirschfield,Michael F. Seldin,Pietro Invernizzi,Katherine A. Siminovitch,Xiong Ma, Minoru Nakamura,George F. Mells
JOURNAL OF HEPATOLOGYno. 4 (2023): 883-883
Lucy M. V. Gee,Ben Barron-Millar,Jack Leslie,Claire Richardson,Marco Y. W. Zaki,Saimir Luli,Rachel A. Burgoyne,Rainie I. T. Cameron,Graham R. Smith,John G. Brain,Barbara Innes,Laura Jopson,Jessica K. Dyson, Katherine R. C. McKay,Alexandros Pechlivanis,Elaine Holmes,Rolando Berlinguer-Palmini,Stella Victorelli,George F. Mells,Richard N. Sandford, Jeremy Palmer,John A. Kirby,Christos Kiourtis,Joao Mokochinski,Zoe Hall,Thomas G. Bird,Lee A. Borthwick,Christopher M. Morris,Peter S. Hanson,Diana Jurk,Elizabeth A. Stoll,Fiona E. N. LeBeau,David E. J. Jones,Fiona Oakley
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#Papers: 180
#Citation: 6785
H-Index: 40
G-Index: 81
Sociability: 8
Diversity: 0
Activity: 1
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