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Research in my laboratory is focused on understanding the role of cell-cell signaling during pituitary development. We hypothesize that the Notch signaling pathway may play an important role in the proliferation and lineage specific differentiation of progenitor cells in the embryonic pituitary. The Notch signaling pathway is an evolutionarily conserved mechanism that orchestrates cell fate choices in a broad spectrum of developmental systems. The core pathway includes two transmembrane ligands, (Delta and Jagged), a transmembrane receptor (Notch), a coactivator (CSL/Rbpsuh) and a downstream transcription factor (Hes). Many components of the Notch pathway are present in the developing pituitary, but their function in this system is unknown.
We are interested in uncovering the role of Notch signaling in the normal development of the pituitary and in pituitary disease. We are exploring if Notch signaling is necessary and sufficient for obtaining the full complement of cells in the pituitary by employing transgenic and knockout mice. These studies also take advantage of molecular genetic techniques and whole animal physiology.
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论文共 81 篇作者统计合作学者相似作者
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Molecular and cellular endocrinology (2024): 112163-112163
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2024)
Julian Martinez-Mayer,Michelle L. Brinkmeier, Sean P. O’Connell, Arnold Ukagwu,Marcelo A. Marti,Mirta Miras, Maria V. Forclaz, Maria G. Benzrihen,Leonard Y. M. Cheung, Sally A. Camper,Buffy S. Ellsworth,Lori T. Raetzman,
Genome Medicineno. 1 (2024): 1-24
Biology of Reproductionno. 1 (2023): 198-210
Reproductive toxicology (Elmsford, N.Y.) (2023): 108427-108427
Reproductive toxicology (Elmsford, N.Y.) (2023): 108489-108489
Karen E. Weis,Lindsay M. Thompson,Madeline Streifer, Isabella Guardado,Jodi A. Flaws,Andrea C. Gore,Lori T. Raetzman
Reproductive Toxicology (2023): 108388-108388
Experimental neurology (2023): 114389
ENDOCRINOLOGYno. 10 (2023)
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