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Three main foci characterize my research. First, we aim to understand transport, cellular signaling and communication across cell membranes at the molecular level. Most recently this includes the first structures of channels in endolysosomes (TPCs) that participate in regulating nutrient acquisition. This gave us the first structure of any resting state voltage sensor, because its voltage sensitivity is tuned by lumenal calcium ions that lead to a ~1% open probability at 0 volts potential across the membrane. Most recently we removed this regulatory site, changing the open probability to ~99% at 0 volts. This gave us the first case of any voltage sensor seen in resting, and in active state in the same voltage gated ion channel. TPCs are critical to Ebola viral fusion and entry via the endolysosome; the structure is bound to an inhibitor NED19 that cures infected mice of Ebola. Another aim is on packaging of neurotransmitters into synaptic vesicles. The second focus is on understanding how macromolecular structure encodes specificity and affinity, at protein - protein and at protein - ligand interfaces, and how this can be used for biotherapeutics and drug design. To these ends we have determined the high-resolution three-dimensional atomic structures of over 330 proteins in many different classes, and used these structures to help define biological, biochemical, and cellular function, and as templates for drug design. We seek to determine the structures of membrane receptors, channels and transporters using X-ray and cryo electron microscopy. We address the cellular partners of HIV proteins in attempts to elucidate novel drug targets for anti-HIV therapy. We also address recently identified essential enzymes and transporters of mycobacterium tuberculosis, and P.falciparum as targets for drug discovery. The third area of focus concerns RNA-protein recognition, specificity and modification. We described and decoded several methylases, pseudouridine synthases showing how they achieve specificity by allosteric alteration of RNA. The most recent of these is the RNA methylase that tailors Lys3 tRNA by methylating the base A58; bases 58-72 act as the primer for HIV reverse transcription. Knockout of this enzyme reduces HIV viral infectivity by ~50%.
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Hemant Kumar, Aayushi Bajaj, Paras Kumar, Rupesh Aggarwal, Vinayak Chalia, Rajesh Kumar Pradhan, Ritu Yadav, Shalini Sinha, Vishad Agarwal, William Harries,Meenakshi Dua,Robert M. Stroud,Atul Kumar Johri
PROTEIN EXPRESSION AND PURIFICATION (2024)
Daphne F Chen,Leah T Roe,Yuping Li,Adair L Borges, Jenny Y Zhang, Palak Babbar, Sourobh Maji, Maisie G V Stevens,Galen J Correy,Morgan E Diolaiti, Dominique H Smith,Alan Ashworth,Robert M Stroud,Mark J S Kelly,Joseph Bondy-Denomy, James S Fraser
bioRxiv the preprint server for biology (2024)
Biophysical journalno. 3 (2024): 396a-396a
Nitesh Kumar Khandelwal,Meghna Gupta,James E Gomez,Sulyman Barkho,Ziqiang Guan, Ashley Y Eng, Tomo Kawate, Sree Ganesh Balasubramani,Andrej Sali, Deborah T Hung,Robert M Stroud
bioRxiv the preprint server for biology (2024)
Boyang Zhao, Zhongzheng Cao,Yi Zheng,Phuong Nguyen,Alisa Bowen,Robert H. Edwards,Robert M. Stroud,Yi Zhou,Menno Van Lookeren Campagne,Fei Li
NATURE COMMUNICATIONSno. 1 (2024)
Journal of Silence Studies in Educationno. 1 (2024): 33-43
Biophysical Journal (2024)
Meghna Gupta,Nitesh Kumar Khandelwal,Andrew Nelson, Peter Hwang,Sergei Pourmal, Jeffrey L Bennett,Robert M Stroud
bioRxiv the preprint server for biology (2024)
Oliver Tavabie,Jane Abbott,Kushala Abeysekera,Vinay K. Balachandrakumar,Kris Bennett,Paul Brennan,Ryan Buchanan, Amritpal Dhaliwal, Vasileios Galanakis, Tim Hardy,Rebecca C. Harris,Victoria Kronsten,Jessica Leighton,Wenhao Li,James Liu Yin,Lucia Macken,Thomas Marjot,James Maurice, Hannah Mcdowell,Janardhan Navaratnam,Keith Pohl,Jeremy S. Nayagam,Emma Saunsbury,J. A. Scott,Abhishek Sheth, Ricky Sinharay,Giovanna Sheiybani,Mohsan Subhani,Lucy Turner,Helen White,Nekisa Zakeri,Charlotte Cook,Nadir Abbas,Abdullah Abbasi, Rahman Abdul,Mohamed Abdulaziz, Duaa Abduljabbar, Robbie Adamson,Danielle Adebayo, Aditya Kumar Adhikarla,Maciej Adler, Sahrim Ahmad, Shayan Ahmed, Mostafa Afifi,Akram Ali, Balqees Al Radhi, Ismaeel Al-Talib, Jolomi Alele,Alaa M. Ali, Safa Almusai,Victoria Appleby, Huma Asmat, Sarah Astbury, Ali Atkinson, Fakhirah Badrulhisham, A. Ball, Moses Banfa, Jeevan Barn, Shahnaz Begum,Katherine Belfield,Oliver Bendall, Rajan Bhandari, Prashan Bhatti, Meg Bradley,Ellie Brown,Kathleen Bryce,Laura Burke, Roisin Campbell,Tamsin Cargill, Geraldine Carroll, James Cartledge,Devnandan Chatterjee, Rayan Chaundry, Zeshan Choudhry,Kathleen Clare, Jeremy Cobbold, Robert A. Coburn, Fintan Corvan,Rebecca Jane Cox, D. Craig,John Creamer,Christopher A. Curran,Shanika De Silva, Laurence Dean, Jayne Dillon, Rebecca L. Dunn,Robert J. Eckersley, Gidveig Eike, Amul Elagib, Ayman Elkholi, Omar Elshaarawy,Sarah Faloon,Si Fan, Mohammad Fazili, Denzil Fernandes,James G. Fox,Matthew Foxton,Waqas Gaba, Girish Gaikwad, Abishek Gairola, Charles Gallaher, Nisham Gautam, Lewis Germain, Ben Giles, Ceri Gill,Ben Glover, John Glover,David Rodríguez Gómez,Michael A. Gómez,Victoria Gordon, Sarah Gormley, John Goulder, Simran Goyal, Olivia Greenham,Sarah Guthrie, Richard Hackett,Yazan Haddadin,Andreas V. Hadjinicolaou,Jonathan Hall, Tasnuma Haque,Catherine K. Hart, Syed Mujtaba Hasnain Nadir, James Hassall, Sundas Hasan, George Hawker-Bond, Jake Hawkyard, Scott Healey, Catherine Hornby,Mohammed F. Hamza, M.D. Humayun, J. L. Hutchison, Zahra Iftikhar, Asem Ismail, Joanna L. James, Laura Jopson, Dipal Juthani, Philippa Kaina, Aadil Karim, Syed Misbah Karim, Vaishnavi Kashyap,Mohamad Kassab,Dev Katarey, L.C. Kenny,Georgina Kerry,Adnan Khan, Ayesha Khan, Azab Khan,Muhammad Taha Khan,Tahir Mehmood Khan, Aseil Khatib,Mohammad Fawad Khattak, Ji Jade King, Mohammed Korani,Sreelakshmi Kotha, Emily Kooner, Wai Liam Lam, Mohammed Abdul Lateef,Damien Leith,Angela Liaros, Floyd Lourenco, Annabel Lyles, Midusa Mahenthiran, Ciarán Magee, Daniel Maggs, Aarani Mahalingam, Rizwan Mahmood, Mandour Omer Mandour, Namita Manocha,Dina Mansour, Daniella Marks, Ciara Martin,Martin Hennenberg, Iana Martin, Katherine J. Martin, Sachan Maruthan, Rhys Masin, Denise Mason,Charmaine Matthews, Athina Mavrou, Ema Maxan, Dominic Maxfield, Emma McAvoy, Kirsty McColl, Hannah McCaughan,Roger McCorry, John McGoran, Stewart McDonald, Stewart McIlwane, Olivia Meakin, Leila Mebarek, Hannah Merrill, Stephanie Michail, Pedram Modarres, Alaa Mohamedali, Yaser Mohammed, Zakiuddin Mohammed, Jaiganesh Mohan, Chloé Monnier, Eilis Moran, Gary R. Morrison,Francesca Moroni, Anas Msaddi, Sarah Mutar, Luis Neto-Pereira, Nahed Ismail, Jennifer Ng, Chinonso Nwoguh, Rebecca O’Kane, Sohail Omar, Abosede Ososanya, Jessiya Veliyankodan Parambil,Jay Patel, Marinos Pericleous, Zeshan Pervais, Anju Phoolchund, Julian Pietrzycki, Lushen Pillay, K. Prabhu, Yesita Rizky F. Putri, Umang Qazi, Khizar Khalid Rafique, Krithivasan Raman, Vaishali Ranade, Francesca Rastelli,Elizabeth Ratcliffe,Deepa Rattehalli, Tufail Raza, Amir Razak, Arun Raghuraman, George Read,Anne Robins,Simon Rushbrook, Mohamed Sarakha, Louise St. Aimee, Ramasamy Saravan,Srishti Sarkar,Solange Serna, Hassnain Shahzad, Mohammed Shamsaldeen, Mohammed Sharip,Jessica Shearer, Adam Sheikh, Michelle Sherwin, Nidhi Shintre, Saket Singhal,Rohit Sinha, Gloria R. Smith, R. T. Smith, Joanne Spicer,Johannes Spoor, Shiva Sreenivasan, Amar Srinivasa,Ankur Srivastava, Georgia Stagg, Jatinder Stanley, Jason Stevenson,Daniel C. Stokes,Robert M. Stroud, Hiba Suliman, Marium Sultana, Nikki Summers, Chloe Sutherland, Rachael Swann,Lynne Sykes, Mostafa Taha, Kwei Eng Tan, Zohaib Tariq, Joshua Jun Ming Tay, Alison Taylor, Amit Thakor, J. C. Tsang, Zaccharie Tyler, Esther Unitt, Edward Volcek, Jack Wischhusen, Iona Watson, Chris Watters, Gemma Wells, Monika Widłak,M. P. Williams,Hazel Woodland, Louise Wren, Souzana Xyda, Julian Yeh,Alison L. Young, Jack Shie Jie Yuan,Guruprasad P. Aithal,William Bernal, John F. Dillon,Brian Hogan,Stuart McPherson,Rebecca Jones, Ian A. Rowe,Victoria Snowdon
Journal of hepatologyno. 4 (2023): e165-e167
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#Papers: 792
#Citation: 48750
H-Index: 109
G-Index: 198
Sociability: 8
Diversity: 0
Activity: 1
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