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We want to develop therapies for acquired and familial cardiac disorders. A current emphassi of our experiments is on Hypertrophic cardiomyopathy (HCM) and Dilated Cardiomyopathy (DCM) are common familial cardiovascular disorders linked to variants in genes encoding proteins of the cardiac sarcomere. There are no cures. Despite decades of basic and clinical research, there are critical gaps in our knowledge concerning how defective biophysical signals in the myocyte influence the function of other cellular compartments of the heart during the clinical course of this disorder. Our experiments employ discovery proteomics and transcriptomics to uncover new mechanisms and possible targets for diagnosis and therapy. The findings are correlated with cardiac and vascular function at various levels of organization, histology, and effects of current and new potential therapies.
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Evan H. Phillips,Vytautas P. Bindokas, Dahee Jung, Jay Teamer,Jan K Kitajewski,R. John Solaro,Beata M Wolska,Steve Seung-Young Lee
biorxiv(2023)
Frontiers in cardiovascular medicine (2023): 1060716-1060716
Paulina Langa, Richard J Marszalek,Chad M Warren,Shamim K Chowdhury,Monika Halas,Ashley Batra, Koreena Rafael-Clyke, Angelie Bacon,Paul H Goldspink,R John Solaro,Beata M Wolska
Paulina Langa,Sanam Shafaattalab,Paul H Goldspink,Beata M Wolska, Aurelia A Fernandes,Glen F Tibbits,R John Solaro
Philosophical transactions of the Royal Society of London. Series B, Biological sciencesno. 1879 (2023): 20220176-20220176
Sanam Shafaatalab,Alison Y Li,Farah Jayousi,Yasaman Maaref,Saif Dababneh,Homa Hamledari,Dina Hosseini Baygi,Tiffany Barszczewski,Balwinder Ruprai, Shayan Jannati,Raghu Nagalingam, Austin M Cool,
bioRxiv : the preprint server for biology (2023)
The FEBS journalno. 22 (2023): 5322-5339
Paul H. Goldspink,Chad M. Warren,Bhairavi Swaminathan,Paulina Langa, Stephanie Niemczyk,Beata M. Wolska,Jan Kitajewski, Pieter P. deTombe,R. John Solaro
Circulationno. Suppl_1 (2022)
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