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Sriram Chandrasekaran
副教授
Department of Biomedical Engineering
College of Engineering, University of Michigan-Ann Arbor;Center for Computational Medicine and Bioinformatics, University of Michigan;The Michigan Institute for Data Science, University of Michigan;Center for Systems Biology, University of Michigan
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个人简介
Research overview
Fighting antibiotic resistance using drug combinations: We are developing software tools (e.g. INDIGO, MAGENTA) to design drug combinations with enhanced potency and reduced potential for developing resistance. We also study pathogen metabolism and pathogen-immune interactions to discover new synergistic antibiotics against M. tuberculosis, S. aureus and other pathogens.
Systems biology algorithms to understand metabolic regulation: Our lab is developing new modeling tools to simulate the activity of thousands of metabolic reactions in a human or microbial cell, giving us a unique systems perspective on metabolic regulation. We have applied the methods that we developed (e.g. PROM, DFA, GEMINI and ASTRIX) to understand microbial, stem-cell, cancer, and brain metabolism using omics datasets.
Fighting antibiotic resistance using drug combinations: We are developing software tools (e.g. INDIGO, MAGENTA) to design drug combinations with enhanced potency and reduced potential for developing resistance. We also study pathogen metabolism and pathogen-immune interactions to discover new synergistic antibiotics against M. tuberculosis, S. aureus and other pathogens.
Systems biology algorithms to understand metabolic regulation: Our lab is developing new modeling tools to simulate the activity of thousands of metabolic reactions in a human or microbial cell, giving us a unique systems perspective on metabolic regulation. We have applied the methods that we developed (e.g. PROM, DFA, GEMINI and ASTRIX) to understand microbial, stem-cell, cancer, and brain metabolism using omics datasets.
研究兴趣
论文共 85 篇作者统计合作学者相似作者
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Cancer Researchno. 6_Supplement (2024): 7306-7306
Cancer Researchno. 9_Supplement (2024): PO3-08
ISCIENCEno. 2 (2024): 109025-109025
biorxiv(2024)
Gabriella Assante,Sriram Chandrasekaran,Stanley Ng,Aikaterini Tourna, Carolina H Chung,Kowsar A Isse,Jasmine L Banks,Ugo Soffientini, Celine Filippi,Anil Dhawan,Mo Liu,Steven G Rozen,
Andrew J. Scott, Alexandra O'Brien,Weihua Zhou,Jie Xu,Sravya Palavalasa,Ayesha Kothari,Kari Wilder-Romans, Angelica Lin,Zitong Zhao, Annabel Yang,Navyateja Korimerla,Erik R. Peterson,
Neuro-oncologyno. Supplement_5 (2023): v275-v275
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Cancer Researchno. 5_Supplement (2023): P2-08
CLINICAL & EXPERIMENTAL METASTASISno. 4 (2023): 373-373
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