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个人简介
My research aims at revealing the molecular mechanisms of cancer cell dissemination and metastasis, beyond doubt the most dismal feature of cancer biology. We apply next-generation sequencing technologies and bioinformatic routines to patient samples including: A. primary tumors of highly metastatic cancer types (e.g. inflammatory breast cancer), B. circulating or disseminated cancer cells, which are cancer cells that are actively metastasizing and C. metastatic lesions (i.e. predominantly liver lesions). Hence, we generate a bird's-eye view of the landscape of molecular alterations relevant to cancer metastasis. Data are then inspected to identify signaling pathways and biological processes with two specific aims: A. to build explanatory models of metastatic cancer cell behavior, allowing identification of key targets for therapy and B. to develop new strategies for patient-tailored cancer treatment based on liquid biopsies. Exemplifying the first aim, we recently showed that deregulated TGFb signaling drives inflammatory breast cancer progression and relates to the formation of disseminating cancer cell emboli. Regarding the latter, we developed a pipeline that allows identification, isolation and characterization of cancer cells harvested from peripheral blood obtained using a simple blood-draw, which offers an easy and low-risk alternative to standard tissue biopsies.
研究兴趣
论文共 384 篇作者统计合作学者相似作者
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Robbe Salembier, Caro De Haes,Julie Bellemans,Kristel Demeyere, Wim Van Den Broeck,Niek N. Sanders,Steven Van Laere,Traci R. Lyons, Evelyne Meyer,Jonas Steenbrugge
Breast Cancer Researchno. 1 (2024): 1-30
Astrid Van den Eynde, Laura Gehrcken, Tias Verhezen, Ho Wa Lau,Christophe Hermans,Hilde Lambrechts,Tal Flieswasser,Delphine Quatannens,Gils Roex,Karen Zwaenepoel,Elly Marcq, Philippe Joye,
Journal of Hematology & Oncologyno. 1 (2024): 1-19
International review of cell and molecular biology (2024): 77-112
Translational Oncology (2024): 101907-101907
Xuemei Xie,Gaurav B Chauhan,Ramakrishna Edupuganti,Takahiro Kogawa,Jihyun Park, Moises Tacam,Alex W Tan,Mohd Mughees, Fnu Vidhu,Diane D Liu,Juliana M Taliaferro, Mary Kathryn Pitner,
Cancer research communicationsno. 1 (2024): 236-236
François Bertucci,Florence Lerebours,Michele Ceccarelli,Arnaud Guille, Najeeb Syed,Pascal Finetti,José Adélaïde,Steven Van Laere,Anthony Goncalves,Patrice Viens, Daniel Birnbaum,Emilie Mamessier,
Journal of Translational Medicineno. 1 (2024): 1-12
crossref(2023)
Maurice P.H.M. Jansen,Theo Knijnenburg,Esther A. Reijm,Iris Simon,Ron Kerkhoven,Marjolein Droog,Arno Velds,Steven van Laere,Luc Dirix,Xanthippi Alexi,John A. Foekens, Lodewyk Wessels,
crossref(2023)
Heather L. Lehman,Steven J. Van Laere, Cynthia M. van Golen,Peter B. Vermeulen,Luc Y. Dirix, Kenneth L. van Golen
crossref(2023)
Research Square (Research Square) (2023)
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