基本信息
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个人简介
Research Interests:
Dr. Stephen B. Liggett's laboratory has several major interrelated initiatives:
The study of the molecular basis of G-protein coupled receptor structure and function
Delineation and characterization of human genetic variants within this receptor signaling network
Association studies of genetic variants with heart and lung disease and their response to treatment to develop a platform for genetically-based personalized medicine
Creation of genetically modified mice to define the mechanisms of heart and lung disease and "humanized mice" to explore the effects of genetic variation of human genes
Determination of the full genome sequences of human Rhinoviruses using high throughput next-generation sequencing technologies; analysis of the relationships between viral genomes and asthma phenotypes
Genomic-based drug discovery, most recently identifying bitter taste receptors on airway smooth muscle and showing that they act to bronchodilate, thus being a potential new therapy for asthma and COPD
研究兴趣
论文共 435 篇作者统计合作学者相似作者
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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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bioRxiv : the preprint server for biology (2023)
Philip D Tatman,David P Kao,Kathryn C Chatfield,Ian A Carroll, Jessica A Wagner, Eric R Jonas,Carmen C Sucharov,J David Port,Brian D Lowes, Wayne A Minobe,Sophia P Huebler,Anis Karimpour-Fard,
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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iScienceno. 4 (2023): 106422-106422
B. Tourki,I. Vera,C. Perrot, F. Farsaei, A. Arsenault,B. Juan-Guardela, D. Allen,R. Restrepo Jaramillo,D. Bandyopadhyay, E. Belli, G. Katlaps,K. Patel,
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Journal of Personalized Medicineno. 331 (2022): 331
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