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Susan Gasser's studies have continued to examine how nuclear organization impinges on mechanisms of repair and replication fork stability and on epigenetic inheritance of cell fate decisions. She exploits the genetics of model organisms in her studies, as well as quantitative live fluorescence imaging. Her laboratory identified mechanisms that tether telomeres and silent chromatin at the nuclear envelope. In parallel, they identified roles for RecQ helicases, checkpoint kinases and ORC in the maintenance of genome integrity. Over the last 10 years she has examined the role of nuclear organization and heterochromatin in the development of the nematode, C. elegans. The laboratory has contributed to our understanding of signals and anchors involved in chromatin positioning, both for active and inactive genes, and for various types of DNA double strand break repair.
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FEBS lettersno. 22 (2023): 2833-2850
Genes & developmentno. 1-2 (2023): 25-26
Nature Cell Biologyno. 7 (2023): 931-932
Marta Rodríguez-Martínez,Jens Nielsen,Sam Dupont,Jessica Vamathevan,Beverley J Glover, Lindsey C Crosswell,Brendan Rouse,Ben F Luisi,Chris Bowler,Susan M Gasser, Detlev Arendt,Tobias J Erb,
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