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Dr. Thomopoulos studies the development and regeneration of the tendon-to-bone attachment. The attachment of dissimilar materials is a major challenge because of the high levels of localized stress that develop at such interfaces. An effective biologic solution to this problem can be seen at the attachment of tendon (a compliant, structural “soft tissue”) to bone (a stiff, structural “hard tissue”). The enthesis, a transitional tissue that exists between uninjured tendon and bone, is not recreated during healing, so surgical reattachment of these two dissimilar biologic materials often fails (e.g., recurrent tears after rotator cuff repair range from 20% to 94%, depending on the patient population. To develop successful strategies for tendon-to-bone repair, necessary for rotator cuff repair and anterior cruciate ligament reconstruction, the Thomopoulos lab seeks to first understand the mechanisms by which the healthy attachment transfers load between tendon and bone, and how cells build a functional attachment during development. In order to achieve these goals, they are focusing on: (I) understanding the structure-function relationships that allow for effective load transfer at the healthy enthesis, (II) determining the biophysical and molecular cues that drive the development of the enthesis, (III) developing regenerative medicine strategies motivated by structure-function and developmental biology results, and (IV) applying these strategies to improve tendon-to-bone healing.
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FASEB journal : official publication of the Federation of American Societies for Experimental Biologyno. 6 (2024): e23568-e23568
Brittany P Marshall, Beth G Ashinsky,Xavier E Ferrer,Jennifer A Kunes, Astia C Innis,Andrew J Luzzi,Lynn Ann Forrester, Kevin G Burt,Andy J Lee,Lee Song, Lauren E Lisiewski,Rajesh K Soni,
FASEB JOURNALno. 6 (2024)
Dianne Little,Peter C Amadio,Hani Awad,Stephanie G Cone,Nathaniel A Dyment,Matthew B Fisher,Alice H Huang,Drew W Koch,Andrew F Kuntz, Rashad Madi, Kirk McGilvrey,Lauren V Schnabel,
Journal of orthopaedic research : official publication of the Orthopaedic Research Society (2023)
Ryan A. Lane,Nicole Migotsky,Necat Havlioglu,Leanne E. Iannucci,Hua Shen,Spencer Lake, Shelly E. Sakiyama-Elbert,Stavros Thomopoulos,Richard H. Gelberman
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Orthopaedic Journal of Sports Medicineno. 7_suppl3 (2023)
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Journal of Bone and Joint Surgeryno. 5 (2023): 417-425
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