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Major areas of emphasis include: 1) elucidation of molecular mechanisms that govern tissue-specific gene expression; 2) molecular mechanisms of antibody diversity, 3) mechanisms controlling T cell memory, and 4) contribution of regulatory immune cells to cancer. As described below for the individual programs, a wide variety of in vitro and in vivo models are employed to approach these issues. These processes have direct relevance to our understanding of critical events associated with various age-related deficits and/or development of age-related diseases including cancer. LMBI investigators also study several aspects of human immunology. These areas of research include: 1) functional changes in immune cell types that occur with age and their contribution to chronic inflammation; 2) properties of age-associated immune subsets and 3) the emergence of autoimmunity in the elderly.
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论文共 152 篇作者统计合作学者相似作者
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Fei Ma,Yaqiang Cao, Hansen Du, Fatima Zohra Braikia,Le Zong, Noah Ollikainen, Marc Bayer,Xiang Qiu,Bongsoo Park,Roshni Roy, Satabdi Nandi,Dimitra Sarantopoulou,
Nature cell biology (2024)
JOURNAL OF EXPERIMENTAL MEDICINEno. 2 (2024)
Cold Spring Harbor perspectives in medicine (2023)
bioRxiv : the preprint server for biology (2023)
crossref(2023)
eLife (2023)
Aging research (Hong Kong, China)no. 1 (2023)
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