基本信息
浏览量:12
职业迁徙
个人简介
By direct observation of molecular events obtained using Lattice Light Sheet Microscopy and Lattice Light Sheet Microscopy optimized with Adaptive Optics (AO-LLSM), frontier optical-imaging modalities with high temporal resolution and spatial precision, we aim to bridge the gap between molecules and cells, either as independent entities in culture, as components of organoids, or as constituents of living tissues. The richness and magnitude of the big-data obtained over periods ranging from seconds to hours create new challenges for obtaining quantitative representations of the observed dynamics and for deriving accurate and comprehensive models for the underlying developmental mechanisms. With these type of dynamic studies we expect to integrate molecular snapshots obtained at molecular and atomic resolution using cryoEM with live-cell processes, in an effort to generate ‘molecular movies' allowing us to obtain frameworks for analyzing some of the molecular contacts and switches that participate in the regulation, availability, and intracellular traffic of the many molecules involved in signal transduction, immune responsiveness, lipid homeostasis, cell-cell recognition and organelle biogenesis. Such biological phenomena have importance for our understanding of many diseases including cancer, viral infection and pathogen invasion, Alzheimer's, as well as other neurological diseases.
研究兴趣
论文共 311 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
crossref(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Lena Tveriakhina,Gustavo Scanavachi,Emily D. Egan, Ricardo Bango Da Cunha Correia, Alexandre P. Martin,Julia M. Rogers, Jeremy S. Yodh, Jon C. Aster,Tom Kirchhausen,Stephen C. Blacklow
Developmental Cell (2024)
Anwesha Sanyal,Gustavo Scanavachi,Elliott Somerville,Anand Saminathan, Athul Nair, Athanasios Oikonomou,Nikos S Hatzakis,Tom Kirchhausen
bioRxiv : the preprint server for biology (2024)
crossref(2023)
crossref(2023)
bioRxiv : the preprint server for biology (2023)
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn