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个人简介
Dr. Maerz’s primary research area is the pathogenesis of post-traumatic osteoarthritis (PTOA) following joint injury, with a specific focus on the synovium and injury-induced molecular mechanisms that modulate the onset of joint degeneration. The Maerz laboratory has a strong translational focus, and each major research platform aims to discover druggable targets to develop novel, disease-modifying treatments for PTOA. Given the expanding incidence of joint injury and the rapidly-growing burden of osteoarthritis and its associated musculoskeletal and non-musculoskeletal comorbidities, a critical need exists to alter the natural history of tissue degeneration following joint injury. Given the complex phenotype of PTOA, the Maerz lab employs multi-faceted assessments to discern in vivo molecular processes, gene and protein expression and content, pain sensitization, pathologic tissue remodeling, and cellular composition. A strong focus is placed on quantitative assessments of PTOA disease severity to minimize or eliminate subjective, qualitative evaluations, and quantitative imaging is used heavily to augment histological and molecular read-outs.
研究兴趣
论文共 91 篇作者统计合作学者相似作者
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Yolande F M Ramos,Sarah J Rice, Shabana Amanda Ali,Chiara Pastrello,Igor Jurisica, Muhammad Farooq Rai, Kelsey H Collins,Annemarie Lang,Tristan Maerz,Jeroen Geurts, Cristina Ruiz-Romero,Ronald K June,
Osteoarthritis and cartilage (2024)
Osteoarthritis and Cartilage (2024): S30-S31
Garth Blackler,Holly Philpott, Joseph D. Klapak,Easton Farrell,Tristan Maerz,Cheryle Seguin,C. Thomas Appleton
Osteoarthritis and Cartilage (2024): S435
Christina Capobianco, Michelle Song, Jeanna Schmanski,Alexis Donneys, Karen Kessell,Tristan Maerz,Kurt Hankenson
Journal of Clinical and Translational Scienceno. s1 (2024): 94-95
Anne-Marie Malfait, Merissa Olmer,Alia Obeidat,Jun Li, Hannah Swahn,Michael Newton, Miguel Otero,Caryn Hale,Frank Ko, Bella Mehta,Tristan Maerz,Dana Orange,
Osteoarthritis and Cartilage (2024): S23-S24
Gurcharan Kaur,James A Pippin, Solomon Chang, Justin Redmond,Alessandra Chesi,Andrew D Wells,Tristan Maerz,Struan F A Grant,Rhima M Coleman,Kurt D Hankenson,Yadav Wagley
JBMR plusno. 5 (2024): ziae051-ziae051
Alexander J Knights,Easton C Farrell,Olivia M Ellis, Michelle J Song,C Thomas Appleton,Tristan Maerz
bioRxiv : the preprint server for biology (2023)
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