基本信息
浏览量:4
职业迁徙
个人简介
Our laboratory focuses on the pathogenesis of emerging and re-emerging viruses that require Biosafety level (BSL)-4 containment and on the development of countermeasures against these viruses. Our work particularly emphasizes studies on viruses causing hemorrhagic fever (HF) including Ebola virus, Marburg virus, and Lassa virus. Efforts focus on: 1) developing, refining and characterizing animal models that accurately reproduce human viral HF infection; 2) identifying critical pathogenic processes of viral HF infections that could be exploited as targets for therapeutic interventions. Particular emphasis is placed on determining the basis of coagulopathy and shock that characterize HF viral infections; and 3) measuring the therapeutic benefits of interrupting pathogenic processes that are important in the development of HF viral infection. Currently, there are no vaccines against Ebola, Marburg, or Lassa viruses approved for use in humans. Our laboratory focuses primarily on using recombinant vesicular stomatitis virus (rVSV) as a vaccine vector for viral HF. We have shown that rVSV-based HF viral vaccines can completely protect nonhuman primates against Ebola HF, Marburg HF, and Lassa fever. Specific interest areas include modifying rVSV vectors for optimal safety and immunogenicity, identifying antigens needed to develop a multiagent vaccine that can protect against major groups of HF viruses, and determining the role of cellular and host immune responses in protection.
研究兴趣
论文共 300 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
EMERGING MICROBES & INFECTIONSno. 1 (2024): 2301061-2301061
SCIENCE TRANSLATIONAL MEDICINEno. 741 (2024): eadl2055-eadl2055
Robert W Cross,Courtney Woolsey, Victor C Chu,Darius Babusis,Roy Bannister,Meghan S Vermillion,Romas Geleziunas,Kimberly T Barrett,Elaine Bunyan, Anh-Quan Nguyen, Tomas Cihlar, Danielle P Porter,
Science (New York, N.Y.)no. 6688 (2024): eadk6176-eadk6176
JOURNAL OF INFECTIOUS DISEASES (2024)
VACCINEno. 3 (2024): 598-607
bioRxiv : the preprint server for biology (2024)
Virusesno. 5 (2023): 1077-1077
Immunono. 4 (2023): 358-374
PATHOGENSno. 12 (2023): 1408
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn