基本信息
浏览量:22
职业迁徙
个人简介
Research Interests
Bioanalytical technologies, In situ single cell omics (Spatially resolved single cell omics), Synthetic cells, Bioimaging, Drop microfluidics
Research Description
The Han group leverages our expertise in microfluidics, bioimaging, nanotechnology, and materials chemistry to invent new bioanalytical technologies. We also implement the new tools to unveil the molecular and cellular mechanisms driving the ensemble behaviors of native biological systems. The followings are the drives of technological innovation in our lab:
Multiscale and multimodal imaging platform
The biology of multicellular organisms is structured at multiple levels. Networks of molecular interactions regulate cell function; Interface of cells with nearby cells and environments further shapes their state and function; Cells form highly interconnected functional networks organ-wide. Imaging is a powerful tool that probes both the molecular profiles and their spatial architecture. The spatial architecture is strongly tied to molecular and cellular interactions as well as higher-level functional networks. We develop imaging platforms that can access different dimensions of biological information at unprecedented scale and resolution. Using the new platform, we study how molecular and cellular interactions contribute to system-level functions. We develop both imaging platforms and data processing methodologies.
Droplet microfluidics-based bioanalytical platforms
Droplet microfluidics holds many advantages for high throughput assays and controlled assembly of functional materials. It compartmentalizes individual cells or molecules into micron-sized drops, allowing unbiased profiling of each analyte at high throughput. The small volume of drops ensures high reaction efficiencies with minimal input materials, providing single molecule sensitivity. Droplet microfluidics also allows controlled encapsulation of molecular machinery into drops and templated formation of functional structures. We develop microfluidic platforms that enable high resolution analysis of complex biological systems.
The specific systems and biological questions we ask constantly evolve, but we are generally interested in brains, tumor tissues, and microbial communities, the system that have inherent heterogeneity and strong intercellular interactions.
研究兴趣
论文共 20 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
biorxiv(2024)
crossref(2023)
ADVANCED FUNCTIONAL MATERIALSno. 37 (2023)
Enrique Valera,Victoria Kindratenko,Aaron M. Jankelow,John Heredia, Alicia Y. Kim, Thomas W. Cowell, Chih-Lin Chen,Karen White,Hee-Sun Han,Rashid Bashir
Current Opinion in Electrochemistry (2023): 101300-101300
Thomas Cowell,Hee-Sun Han
Methods in molecular biology (Clifton, N.J.) (2023): 155-167
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