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The Wu laboratory of “structural immunology” focuses on elucidating the molecular mechanism of signal transduction by immune receptors, especially innate immune receptors. The lab began its studies on the signaling of a classical cytokine produced by the innate immune system, tumor necrosis factor (TNF), which induces diverse cellular responses such as NF-κB activation and cell death. Receptors for TNF belong to the large TNF receptor (TNFR) superfamily. The second pursuit of the lab has been the Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) superfamily, which induces signaling pathways overlapping with those of the TNFR superfamily. TLRs are transmembrane receptors that sense a discrete collection of molecules of microbial origin in the extracellular space and endosomes and members of IL-1R family are receptors for cytokines IL-1 and IL-18. In recent years, the lab expanded its research to a number of cytosolic pattern recognition receptors that provide intracellular surveillance of infections. Some of these receptors form inflammasomes to control activation of caspase-1, which in turn regulates maturation of the proinflammatory cytokines IL-1 and IL-18 and induces pyroptosis, a rapid inflammatory form of cell death.
In addition, the lab initiated an effort to elucidate the molecular mechanism for the generation of antigen receptor diversity in adaptive immunity. For optimal host defense, jawed vertebrates have evolved the elegant V(D)J recombination to generate a large repertoire of antibody and antigen-receptor genes. The RAG recombinase specifically recognizes and cleaves variable (V), diversity (D) and joining (J) non-contiguous immunoglobulin (Ig) segments in the genome, which then become spliced together by the nonhomologous end joining (NHEJ) DNA repair pathway.
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论文共 623 篇作者统计合作学者相似作者
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Journal of Biological Chemistryno. 3 (2024)
Natureno. 7991 (2024): 1-1
Nature Communicationsno. 1 (2024): 1-17
Runzhi Li, Yang Zan,Decai Wang, Xuequn Chen,Anmin Wang, Haoyuan Tan,Guorong Zhang,Siyuan Ding,Chen Shen,Hao Wu,Shu Zhu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 6 (2024): e2321419121-e2321419121
Cell (2024)
Qianman Peng, Kulandai Samy S. Arulsamy,Yao Wei W. Lu,Kui K. Cui,Bo Zhu, Bandana Singh,Hao Wu,Sudarshan Bhattacharjee,Kathryn S. Li,Jill Wylie-Sears,Scott Wong, Douglas B. Cowan,
ASPET 2024 Annual Meeting Abstract - Cardiovascular Pharmacology (2024)
COLD SPRING HARBOR PERSPECTIVES IN MEDICINEno. 1 (2024): a041165-a041165
Gang Du, Liam B Healy,Liron David,Caitlin Walker,Tarick J El-Baba,Corinne A Lutomski,Byoungsook Goh, Bowen Gu,Xiong Pi,Pascal Devant,Pietro Fontana,Ying Dong,
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