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研究方向:(1)自身免疫性肝病的病因学研究原发性胆汁性胆管炎(Primary Biliary Cholangitis,PBC)是一种以肝内小胆管进行性损伤和炎症细胞浸润为主要特点的自身免疫性疾病。PBC多发于45岁以上的中老年人,以女性患者为主,具有很强的遗传易感性。本课题组以中国汉族人群PBC患者为对象(对列研究和家系分析),采用外显子组测序和SNP分型的方法,分析PBC易感基因的多态性以及少见或罕见突变,并针对相关基因进行功能性分析研究,深入探讨PBC的发病机理。同时我们课题组也开展对PBC诊断标志物的研究,完善PBC特异性自身抗体的检测体系。(2)肥厚型心肌病致病基因的筛选和功能分析肥厚型心肌病(Hypertrophic Cardiomyopathy,HCM)是一种常见的遗传性疾病,在人群中的发病率为0.02%-0.2%,HCM是猝死的主要原因之一。HCM的发生主要是由于与心肌发育和功能相关的基因突变造成的,是一种典型的多基因造成的遗传疾病。目前已有近30个基因的突变与HCM相关,但仍然有近20%的HCM患者的突变基因未知。本课题组采用外显子组测序的方法寻找到多个HCM突变基因,并进行相关的功能性研究。
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Papers共 110 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of Translational Autoimmunity (2024): 100239
Xingjuan Shi, Jiayu Yao, Yexi Huang, Yushan Wang,Xuan Jiang, Ziwen Wang,Mingming Zhang,Yu Zhang,Xiangdong Liu
Journal of Biological Chemistrypp.107335, (2024)
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY (2024)
Experimental Cell Researchno. 1 (2024): 114072-114072
Peng Jiang,Chan Wang,Mingming Zhang,Ye Tian,Weifeng Zhao,Junyi Xin, Yexi Huang,Zhibin Zhao,Wenjuan Sun,Jie Long,Ruqi Tang,Fang Qiu,Xingjuan Shi, Yi Zhao,Li Zhu,Na Dai,Lei Liu,Xudong Wu,Jinshan Nie,Bo Jiang,Youlin Shao,Yueqiu Gao,Jianjiang Yu,Zhigang Hu,Zhidong Zang,Yuhua Gong,Yaping Dai,Lan Wang,Ningling Ding,Ping Xu,Sufang Chen,Lu Wang,Jing Xu,Luyao Zhang, Junyan Hong, Ruonan Qian, Hu Li,Xuan Jiang, Congwei Chen,Wenyan Tian,Jian Wu,Yuzhang Jiang,Chongxu Han,Kui Zhang,Hong Qiu, Li,Hong Fan,Liming Chen,Jianqiong Zhang,Zhongsheng Sun, Xiao Han, Zhenhua Dai,Erguang Li,M Eric Gershwin,Zhexiong Lian,Xiong Ma,Michael F Seldin,Weichang Chen,Meilin Wang,Xiangdong Liu
Dong Hwan (Dennis) Kim,Lakshmi Sriharsha,Wei Xu,Suzanne Kamel-Reid,Xiangdong Liu,Katherine Siminovitch,Hans Messner,Jeffrey Lipton
pubmed(2023)
SHS Web of Conferences (2023): 04006-04006
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Author Statistics
#Papers: 111
#Citation: 4300
H-Index: 23
G-Index: 62
Sociability: 6
Diversity: 4
Activity: 23
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